Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei, University School of Medicine, 3-25- 8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.
Curr Med Chem. 2012;19(35):6009-17.
Currently many efforts are being made to apply regenerative medicine to kidney diseases using several types of stem/progenitor cells, such as mesenchymal stem cells, renal stem/progenitor cells, embryonic stem cells and induced pluripotent stem cells. Stem cells have the ability to repair injured organs and ameliorate damaged function. The strategy for kidney tissue repair is the recruitment of stem cells and soluble reparative factors to the kidney to elicit tissue repair and the induction of dedifferentiation of resident renal cells. On the other hand, where renal structure is totally disrupted, absolute kidney organ regeneration is needed to rebuild a whole functional kidney. In this review, we describe current advances in stem cell research for kidney tissue repair and de novo organ regeneration.
目前，许多研究都在利用多种类型的干细胞/祖细胞（如间充质干细胞、肾干细胞/祖细胞、胚胎干细胞和诱导多能干细胞）来应用再生医学治疗肾脏疾病。干细胞具有修复受损器官和改善受损功能的能力。肾脏组织修复的策略是招募干细胞和可溶性修复因子到肾脏，以引发组织修复，并诱导固有肾脏细胞去分化。另一方面，在肾脏结构完全被破坏的情况下，需要绝对的肾脏器官再生来重建整个功能肾脏。在这篇综述中，我们描述了干细胞研究在肾脏组织修复和从头器官再生方面的最新进展。
