Bachelerie Françoise, Graham Gerard J, Locati Massimo, Mantovani Alberto, Murphy Philip M, Nibbs Robert, Rot Antal, Sozzani Silvano, Thelen Marcus
INSERM UMR-S996, Laboratory of Excellence in Research on Medication and Innovative Therapeutics, Université Paris-Sud, Clamart, France.
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK.
Br J Pharmacol. 2015 Aug;172(16):3945-9. doi: 10.1111/bph.13182. Epub 2015 Jun 26.
Chemokines and their receptors are essential regulators of in vivo leukocyte migration and, some years ago, a systematic nomenclature system was developed for the chemokine receptor family. Chemokine receptor biology and biochemistry was recently extensively reviewed. In this review, we also highlighted a new component to the nomenclature system that incorporates receptors previously known as 'scavenging', or 'decoy', chemokine receptors on the basis of their lack of classical signalling responses to ligand binding and their general ability to scavenge, or sequester, their cognate chemokine ligands. These molecules are now collectively referred to as 'atypical chemokine receptors', or ACKRs, and play fundamental roles in regulating in vivo responses to chemokines. This commentary highlights this new addition to the chemokine receptor nomenclature system and provides brief information on the four receptors currently covered by this nomenclature.
趋化因子及其受体是体内白细胞迁移的重要调节因子，几年前，趋化因子受体家族建立了一个系统的命名体系。最近，有关趋化因子受体生物学和生物化学的内容已有广泛综述。在本综述中，我们还强调了命名体系中的一个新成员，该成员纳入了以前被称为“清除性”或“诱饵”趋化因子受体的分子，这些受体基于其对配体结合缺乏经典信号反应以及清除或隔离其同源趋化因子配体的一般能力。这些分子现在统称为“非典型趋化因子受体”（ACKRs），在调节体内对趋化因子的反应中发挥着重要作用。本述评突出了趋化因子受体命名体系中的这一新增内容，并简要介绍了目前该命名体系涵盖的四种受体。
