Jin Sung Giu, Yousaf Abid Mehmood, Jang Sun Woo, Son Mi-Won, Kim Kyung Soo, Kim Dong-Wuk, Li Dong Xun, Kim Jong Oh, Yong Chul Soon, Choi Han-Gon
College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, 426-791, South Korea.
Pharmaceutical Product Research Laboratories, Dong-A Pharm. Co. Ltd., Yongin-Si, Kyunggi-Do, 449-905, South Korea.
Drug Dev Res. 2015 May;76(3):157-65. doi: 10.1002/ddr.21253. Epub 2015 May 8.
The purpose of this study was to evaluate the wound-healing effects of a novel benzalkonium chloride (BC)-loaded hydrocolloid wound dressing (HCD). A BC-loaded HCD was prepared with various constituents using a hot melting method, and its mechanical properties and antimicrobial activities were assessed. The in vivo wound healings of the BC-loaded HCD in various would models were evaluated in rats compared with a commercial wound dressing, Duoderm™. This BC-loaded HCD gave better skin adhesion, swelling, mechanical strength, and flexibility compared with the commercial wound dressing. It showed excellent antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. In addition, as compared with the commercial wound dressing, it showed more improved wound healings and tissue restoration effect on the excision, infection, and abrasion wounds in rats. Thus, this novel BC-loaded HCD would be an excellent alternative to the commercial wound dressing for treatment of various wounds.
本研究的目的是评估一种新型载苯扎氯铵（BC）的水胶体伤口敷料（HCD）的伤口愈合效果。采用热熔法制备了含有不同成分的载BC的HCD，并对其机械性能和抗菌活性进行了评估。与市售伤口敷料Duoderm™相比，在大鼠的各种伤口模型中评估了载BC的HCD的体内伤口愈合情况。与市售伤口敷料相比，这种载BC的HCD具有更好的皮肤粘附性、肿胀度、机械强度和柔韧性。它对金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌表现出优异的抗菌活性。此外，与市售伤口敷料相比，它在大鼠的切除、感染和擦伤伤口上显示出更显著的伤口愈合和组织修复效果。因此，这种新型载BC的HCD将是治疗各种伤口的市售伤口敷料的极佳替代品。
