Kincse Gyöngyvér, Bhattoa Pál Harjit, Herédi Emese, Varga József, Szegedi Andrea, Kéri Judit, Gaál János
Department of Rheumatology, "Kenézy Gyula" Hospital, Debrecen, Hungary.
Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
J Dermatol. 2015 Jul;42(7):679-84. doi: 10.1111/1346-8138.12876. Epub 2015 May 11.
Limited data are available on the vitamin D3 status and bone mineral density (BMD) of patients with psoriasis or with psoriatic arthritis. Our study intended to explore possible correlations between vitamin D status and BMD, as well as among these parameters and the features of the underlying disorder. Seventy-two patients with psoriasis/or psoriatic arthritis (female : male ratio, 40:32; mean age, 58.5 ± 11.6 years; mean duration of follow up, 142.7 ± 147.7 months) participated in the study. We evaluated the characteristic clinical features of the underlying disease, performed bone densitometry of the lumbar spine and the hip region, measured the serum vitamin 25(OH)D3 levels of the patients, and undertook the statistical analysis of the relationships between the clinical and the laboratory parameters. The proportion of patients with a low BMD value did not exceed that seen in the general population. We found an inverse correlation between the serum level of vitamin 25(OH)D3 and body mass index, as well as between the former and the severity of skin involvement. Furthermore, the activity of psoriatic arthritis was significantly higher in patients with inadequate vitamin D3 status. In patients with psoriatic arthritis, BMD significantly exceeded the values measured in patients suffering from psoriatic skin lesions only. Our findings suggest the importance of evaluating the vitamin D3 status and screening for comorbid conditions in patients with psoriasis or psoriatic arthritis. This appears justified, in particular, due to the possible role of hypovitaminosis D3 in provoking the development of skin lesions and joint symptoms.
关于银屑病或银屑病关节炎患者的维生素D3状态和骨密度（BMD）的数据有限。我们的研究旨在探讨维生素D状态与骨密度之间以及这些参数与潜在疾病特征之间可能存在的相关性。72例银屑病/或银屑病关节炎患者（女性：男性比例为40:32；平均年龄58.5±11.6岁；平均随访时间142.7±147.7个月）参与了该研究。我们评估了潜在疾病的特征性临床特征，对腰椎和髋部区域进行了骨密度测定，测量了患者血清维生素25(OH)D3水平，并对临床和实验室参数之间的关系进行了统计分析。骨密度值低的患者比例未超过普通人群中的比例。我们发现血清25(OH)D3水平与体重指数之间以及前者与皮肤受累严重程度之间呈负相关。此外，维生素D3状态不足的患者中银屑病关节炎的活动度明显更高。在银屑病关节炎患者中，骨密度显著超过仅患有银屑病皮肤病变患者的测量值。我们的研究结果表明，评估银屑病或银屑病关节炎患者的维生素D3状态和筛查合并症具有重要意义。特别是考虑到维生素D3缺乏在引发皮肤病变和关节症状发展中可能起到的作用，这样做似乎是合理的。
