MD, MSc, PhD. Researcher, Physician and Professor, Núcleo de Pesquisa em Dermatologia (NUPEDE), Faculty of Medicine, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora (MG), Brazil.
Researcher, Núcleo de Pesquisa e Inovação em Ciências da Saúde (NUPICS), Faculty of Pharmacy, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora (MG), Brazil.
Sao Paulo Med J. 2022 Sep 6;141(3):e2022216. doi: 10.1590/1516-3180.2022.0216.R1.01072022. eCollection 2022.
Psoriasis is a systemic, immune-mediated disease characterized by inflammatory manifestations in the skin and joints. Vitamin D deficiency is currently considered a pandemic and is associated with comorbidities including psoriasis and psoriatic arthritis (PsA).
To determine the prevalence of hypovitaminosis D [25(OH)D] in patients with plaque psoriasis, with and without PsA, and of independent predictors of serum 25(OH)D levels.
Retrospective cross-sectional study conducted among 300 patients at an outpatient clinic in a university center in Juiz de Fora, Minas Gerais, Brazil.
Demographic and clinical data (psoriasis area and severity index [PASI], family history, age at onset, disease duration, and the presence of PsA according to Classification Criteria for Psoriatic Arthritis), skin phototype, and season of the year were reviewed.
Hypovitaminosis D (< 30 ng/mL) was highly prevalent in patients with psoriasis with and without PsA (82.2% and 74.9%, respectively). An inverse correlation between PASI and vitamin D was found (without PsA r = -0.59 and, PsA r = -0.52, P < 0.001), and multivariate regression revealed that hypovitaminosis D was associated with disease severity, season, and phototype. It was confirmed by binary logistic regression between PASI and vitamin D deficiency (< 30 ng/mL), (odds ratio, OR 1.78 CI: -0.20-0.53, P < 0.001).
Hypovitaminosis D (< 30 ng/mL) was highly prevalent in psoriatic patients with and without PsA. Season and skin phototype were associated with 25(OH)D levels. An inverse association between PASI and serum 25(OH)D levels was established.
银屑病是一种全身性、免疫介导的疾病，其特征为皮肤和关节的炎症表现。目前认为维生素 D 缺乏是一种流行疾病，与银屑病和银屑病关节炎（PsA）等合并症有关。
确定斑块型银屑病患者、伴或不伴 PsA 患者中维生素 D 缺乏（25 羟维生素 D [25(OH)D]）的患病率，并确定血清 25(OH)D 水平的独立预测因素。
在巴西米纳斯吉拉斯州茹伊斯-迪福拉的一所大学中心的门诊诊所中进行的回顾性横断面研究。
回顾了患者的人口统计学和临床数据（银屑病面积和严重程度指数 [PASI]、家族史、发病年龄、疾病持续时间以及是否符合 PsA 分类标准）、皮肤光型和一年中的季节。
患有和不患有 PsA 的银屑病患者中维生素 D 缺乏症（<30ng/mL）的患病率均很高（分别为 82.2%和 74.9%）。在没有 PsA 的患者中，PASI 与维生素 D 之间存在负相关（r=-0.59，P<0.001），在有 PsA 的患者中，PASI 与维生素 D 之间存在负相关（r=-0.52，P<0.001）。多元回归显示，维生素 D 缺乏与疾病严重程度、季节和皮肤光型有关。通过 PASI 与维生素 D 缺乏症（<30ng/mL）之间的二项逻辑回归证实了这一点（优势比，OR 1.78，CI：-0.20-0.53，P<0.001）。
患有和不患有 PsA 的银屑病患者中维生素 D 缺乏症（<30ng/mL）的患病率均很高。季节和皮肤光型与 25(OH)D 水平有关。建立了 PASI 与血清 25(OH)D 水平之间的负相关关系。
