Karnes Jonathan M, Daffner Scott D, Watkins Colleen M
Department of Orthopaedics, West Virginia University, Morgantown, WV, United States.
Bone. 2015 Sep;78:87-93. doi: 10.1016/j.bone.2015.05.001. Epub 2015 May 8.
This review presents a summary of basic science evidence examining the influence of tumor necrosis factor-alpha (TNF-α) on secondary fracture healing. Multiple studies suggest that TNF-α, in combination with the host reservoir of peri-fracture mesenchymal stem cells, is a main determinant in the success of bone healing. Disease states associated with poor bone healing commonly have inappropriate TNF-α responses, which likely contributes to the higher incidence of delayed and nonunions in these patient populations. Appreciation of TNF-α in fracture healing may lead to new therapies to augment recovery and reduce the incidence of complications.
本综述总结了基础科学证据，探讨肿瘤坏死因子-α（TNF-α）对二期骨折愈合的影响。多项研究表明，TNF-α与骨折周围间充质干细胞的宿主储备相结合，是骨愈合成功的主要决定因素。与骨愈合不良相关的疾病状态通常具有不适当的TNF-α反应，这可能导致这些患者群体中延迟愈合和不愈合的发生率较高。了解TNF-α在骨折愈合中的作用可能会带来新的治疗方法，以促进恢复并降低并发症的发生率。
