Cui X, Green M A, Blower P J, Zhou D, Yan Y, Zhang W, Djanashvili K, Mathe D, Veres D S, Szigeti K
King's College London, Division of Imaging Sciences and Biomedical Engineering, 4th Floor of Lambeth wing, St Thomas Hospital, London SE1 7EH, UK.
Chem Commun (Camb). 2015 Jun 7;51(45):9332-5. doi: 10.1039/c5cc02259b.
Magnetic and fluorescent hydroxyapatite nanoparticles were synthesised using Al(OH)3-stabilised MnFe2O4 or Fe3O4 nanoparticles as precursors. They were readily and efficiently radiolabelled with (18)F. Bisphosphonate polyethylene glycol polymers were utilised to endow the nanoparticles with excellent colloidal stability in water and to incorporate cyclam for high affinity labelling with (64)Cu.
使用Al(OH)₃稳定的MnFe₂O₄或Fe₃O₄纳米颗粒作为前驱体合成了磁性和荧光羟基磷灰石纳米颗粒。它们很容易且高效地用¹⁸F进行放射性标记。利用双膦酸盐聚乙二醇聚合物赋予纳米颗粒在水中优异的胶体稳定性,并引入环胺用于与⁶⁴Cu进行高亲和力标记。