载阿托伐他汀钙的 NLC 漂浮微球的研制及特性研究，以提高口服生物利用度。
Development and characterization of floating spheroids of atorvastatin calcium loaded NLC for enhancement of oral bioavailability.
机构信息
a Department of Pharmaceutics , ISF College of Pharmacy , Moga, Punjab , India.
出版信息
Artif Cells Nanomed Biotechnol. 2016 Sep;44(6):1448-56. doi: 10.3109/21691401.2015.1041637. Epub 2015 May 9.
OBJECTIVE
The obejctive of the present study was to investigate the potential use of floating spheroids of Atorvastatin Calcium (ATS) Loaded nanostructured lipid carriers (NLCs).
MATERIALS AND METHODS
The final formula of floating spheroids was optimized on the basis of shape (spherical), diameter (0.47 mm), lag time (20 s), and floating time (> 32 h).
RESULTS
The results were further confirmed by different pharmacokinetic parameters-it was observed that the developed optimized floating ATS spheroid-loaded NLCs formulation has significantly improved relative bioavailability, that is, 3.053-folds through oral route in comparison to marketed formulation.
目的
本研究旨在探讨阿伐他汀钙（ATS）负载纳米结构脂质载体（NLCs）漂浮微球的潜在应用。
材料与方法
基于形状（球形）、直径（0.47mm）、滞后时间（20s）和漂浮时间（＞32h）对漂浮微球的最终配方进行优化。
结果
通过不同的药代动力学参数进一步证实了这一结果，与市售制剂相比，所开发的优化的阿伐他汀钙漂浮载药 NLCs 制剂的口服相对生物利用度显著提高，达到 3.053 倍。
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