Woodcock Eric A, White Richard, Diwadkar Vaibhav A
Department of Psychiatry and Behavioral Neurosciences, and Translational Neuroscience Program, Wayne State University School of Medicine, Detroit, MI, USA.
Department of Psychiatry and Behavioral Neurosciences, and Translational Neuroscience Program, Wayne State University School of Medicine, Detroit, MI, USA.
Behav Brain Res. 2015 Sep 1;290:152-60. doi: 10.1016/j.bbr.2015.04.050. Epub 2015 May 7.
Cognitive control includes processes that facilitate execution of effortful cognitive tasks, including associative memory. Regions implicated in cognitive control during associative memory include the dorsal prefrontal (dPFC) and dorsal anterior cingulate cortex (dACC). Here we investigated the relative degrees of network-related interactions originating in the dPFC and dACC during oscillating phases of associative memory: encoding and cued retrieval. Volunteers completed an established object-location associative memory paradigm during fMRI. Psychophysiological interactions modeled modulatory network interactions from the dPFC and dACC during memory encoding and retrieval. Results were evaluated in second level analyses of variance with seed region and memory process as factors. Each seed exerted differentiable modulatory effects during encoding and retrieval. The dACC exhibited greater modulation (than the dPFC) on the fusiform and parahippocampal gyrus during encoding, while the dPFC exhibited greater modulation (than the dACC) on the fusiform, hippocampus, dPFC and basal ganglia. During retrieval, the dPFC exhibited greater modulation (than the dACC) on the parahippocampal gyrus, hippocampus, superior parietal lobule, and dPFC. The most notable finding was a seed by process interaction indicating that the dACC and the dPFC exerted complementary modulatory control on the hippocampus during each of the associative memory processes. These results provide evidence for differentiable, yet complementary, control-related modulation by the dACC and dPFC, while establishing the primacy of dPFC in exerting network control during both associative memory phases. Our approach and findings are relevant for understanding basic processes in human memory and psychiatric disorders that impact associative memory-related networks.
认知控制包括促进执行需要努力的认知任务的过程，包括联想记忆。在联想记忆过程中涉及认知控制的脑区包括背侧前额叶（dPFC）和背侧前扣带回皮质（dACC）。在此，我们研究了在联想记忆的振荡阶段（编码和线索提取）中，源自dPFC和dACC的网络相关相互作用的相对程度。志愿者在功能磁共振成像（fMRI）期间完成了一个既定的物体-位置联想记忆范式。心理生理相互作用模型模拟了在记忆编码和提取过程中来自dPFC和dACC的调节性网络相互作用。结果在以种子区域和记忆过程为因素的二级方差分析中进行评估。每个种子区域在编码和提取过程中都发挥了不同的调节作用。在编码过程中，dACC对梭状回和海马旁回的调节作用（比dPFC）更强，而dPFC对梭状回、海马、dPFC和基底神经节的调节作用（比dACC）更强。在提取过程中，dPFC对海马旁回、海马、顶上小叶和dPFC的调节作用（比dACC）更强。最显著的发现是种子区域与过程的相互作用，表明在每个联想记忆过程中，dACC和dPFC对海马发挥互补的调节控制作用。这些结果为dACC和dPFC不同但互补的与控制相关的调节作用提供了证据，同时确立了dPFC在两个联想记忆阶段发挥网络控制作用中的首要地位。我们的方法和发现对于理解人类记忆的基本过程以及影响与联想记忆相关网络的精神疾病具有重要意义。
