Rotman Research Institute, Baycrest Health Sciences, University of Toronto, Canada.
Rotman Research Institute, Baycrest Health Sciences, University of Toronto, Canada; Department of Psychology, University of Toronto, Canada; Department of Psychiatry, University of Toronto, Canada.
Neuroimage. 2018 Feb 15;167:211-223. doi: 10.1016/j.neuroimage.2017.11.032. Epub 2017 Nov 20.
It is known that prior knowledge can facilitate memory acquisition. It is unclear, however, whether prior knowledge can affect post-encoding brain activity to facilitate memory consolidation. In this fMRI study, we asked participants to associate novel houses with famous/nonfamous faces and investigated how associative-encoding tasks with/without prior knowledge differentially affected post-encoding brain connectivity during rest. Besides memory advantages in the famous condition, we found that post-encoding hippocampal connectivity with the fusiform face area (FFA) and ventral-medial-prefrontal cortex (vmPFC) was stronger following encoding of associations with famous than non-famous faces. Importantly, post-encoding functional connectivity between the hippocampus (HPC) and FFA, and between the anterior temporal pole region (aTPL) and posterior perceptual regions (i.e., FFA and the parahippocampal place area), together predicted a large proportion of the variance in subsequent memory performance. This prediction was specific for face-house associative memory, not face/house item memory, and only in the famous condition where prior knowledge was involved. These results support the idea that when prior knowledge is involved, the HPC, vmPFC, and aTPL, which support prior episodic, social-evaluative/schematic, and semantic memories, respectively, continue to interact with each other and posterior perceptual brain regions during the post-encoding rest to facilitate off-line processing of the newly formed memory, and enhance memory consolidation.
已知先前的知识可以促进记忆的获取。然而，先前的知识是否会影响编码后的大脑活动以促进记忆的巩固尚不清楚。在这项 fMRI 研究中，我们要求参与者将新的房屋与著名/非著名的面孔联系起来，并研究在休息时，具有/不具有先前知识的联想编码任务如何以不同的方式影响编码后的大脑连接。除了在著名面孔条件下的记忆优势外，我们发现，在与著名面孔而不是非著名面孔进行联想编码后，海马体与梭状回面孔区（FFA）和腹内侧前额叶皮层（vmPFC）的连接在编码后更强。重要的是，海马体（HPC）与 FFA 之间以及前颞极区（aTPL）与后感知区（即 FFA 和海马旁回位置区）之间的编码后功能连接，共同预测了随后记忆表现的很大一部分方差。这种预测是特定于面孔-房屋联想记忆的，而不是面孔/房屋项目记忆的，并且仅在涉及先前知识的著名面孔条件下才有效。这些结果支持了这样一种观点，即当涉及先前的知识时，分别支持先前的情景记忆、社会评价/图式记忆和语义记忆的海马体、vmPFC 和 aTPL，在编码后的休息期间继续相互作用，并与后感知大脑区域相互作用，以促进新形成的记忆的离线处理，并增强记忆巩固。
