Risk factors for extensive drug-resistance and mortality in geriatric inpatients with bacteremia caused by Acinetobacter baumannii.

BACKGROUND

The aim of this study was to explore the risk factors for developing bacteremia caused by extensive drug-resistant (XDR) Acinetobacter baumannii and the associated mortality in geriatric inpatients.

METHODS

We conducted a retrospective study of 125 patients with A baumannii bacteremia between October 2008 and December 2013 at a medical center in China.

RESULTS

The 30-day hospital mortality rate was 55.2%. XDR A baumannii was detected in 31.2% of all cases. A logistic regression analysis suggested that chronic obstructive pulmonary disease, a bedridden status, and central venous catheters were associated with bacteremia caused by XDR A baumannii, with adjusted odds ratios (aORs) and 95% confidence intervals (CIs) of 2.59 (1.01-6.64), 4.08 (1.39-12.01), and 9.52 (1.90-47.56), respectively. Furthermore, intensive care unit (ICU) stay, bacteremia caused by XDR A baumannii, concurrent fungal infection, and age (70-80 years old and >80 years old) were associated with mortality, with aORs and 95% CIs of 3.16 (1.29-7.73), 4.01 (1.46-11.04), 3.20 (1.28-7.98), 4.31 (1.44-12.92), and 5.46 (1.94-15.35), respectively.

CONCLUSION

Bacteremia is associated with a high 30-day hospital mortality rate in geriatric inpatients. Furthermore, ICU stay, bacteremia caused by XDR A baumannii, concurrent fungal infection, and age are associated with increased mortality in geriatric inpatients with A baumannii bacteremia.