Andrianov I G, Dobkin A N, Kiselev O I, Okulov V B, Semiglazov V F
Vopr Onkol. 1989;35(10):1186-91.
The study included 10 female donors, 12 patients with benign and 59 with malignant tumors of the breast at various stages before and after treatment. The immunomodulating effect of vasopressin and interleukin-2 on blood-natural killer functional activity was studied in vitro. Vasopressin dose of 4 x 10(-1) IU/5 x 10(5) cells exerted an immunosuppressive effect while 4 x 10(-5) IU/5 x 10(5) cells stimulated immunity. The stimulating effect of optimal interleukin-2 dosage (20-40 U/5 x 10(5) cells) on natural killer functional activity appeared 1.5-2-times higher than that optimal vasopressin dose (4 x 10(-5)/5 x 10(5) cells). Combined administration of the agents was not followed by increase in overall effect. Sensitivity of blood-natural killer cells in breast cancer patients to vasopressin and interleukin-2 depended upon clinical pattern, stage of tumor and treatment modality.
该研究纳入了10名女性供者、12名患有乳腺良性肿瘤的患者以及59名处于治疗前后不同阶段的乳腺恶性肿瘤患者。在体外研究了血管加压素和白细胞介素-2对血液中自然杀伤细胞功能活性的免疫调节作用。4×10⁻¹IU/5×10⁵个细胞剂量的血管加压素发挥免疫抑制作用，而4×10⁻⁵IU/5×10⁵个细胞剂量的血管加压素则刺激免疫。最佳白细胞介素-2剂量（20 - 40 U/5×10⁵个细胞）对自然杀伤细胞功能活性的刺激作用比最佳血管加压素剂量（4×10⁻⁵/5×10⁵个细胞）高1.5至2倍。联合使用这些药物并未使总体效果增加。乳腺癌患者血液中自然杀伤细胞对血管加压素和白细胞介素-2的敏感性取决于临床类型、肿瘤分期和治疗方式。
