Lasisi T J, Shittu S T, Oguntokun M M, Tiamiyu N A
Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria ; Department of Oral Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Ann Ib Postgrad Med. 2014 Dec;12(2):109-14.
The role of aging on the salivary gland function still remains controversial and inconclusive. This study was undertaken to determine the effects of aging on the morphology and secretion of salivary glands using male Wistar rats.
There were three age groups; group A (3 months old; n = 8), group B (6 months old; n = 8), and group C (9 months old; n = 8). Body weights, salivary gland weights, salivary flow rates, pH and salivary levels of sodium, potassium, calcium, chloride, bicarbonate, phosphate and total protein were measured and compared. Hematoxylin-eosin stained histological slides of the salivary glands were assessed for morphological changes.
Body weights increased with age while mean parotid gland weight was significantly higher in group B than in groups A and C. Mean salivary flow rate was significantly higher in group B and C than in group A, and mean salivary pH was significantly higher in group B and C than group A. Analysis of salivary electrolytes and total protein showed that mean levels of sodium, potassium and bicarbonate increased with age significantly while mean levels of calcium, chloride, phosphate and total protein did not show significant change among the groups.
These findings showed that varying changes were observed in the morphology of salivary glands of aging rats without impaired function.
衰老对唾液腺功能的作用仍存在争议且尚无定论。本研究旨在利用雄性Wistar大鼠确定衰老对唾液腺形态和分泌的影响。
分为三个年龄组；A组（3个月龄；n = 8），B组（6个月龄；n = 8），C组（9个月龄；n = 8）。测量并比较体重、唾液腺重量、唾液流速、pH值以及唾液中钠、钾、钙、氯、碳酸氢盐、磷酸盐和总蛋白的水平。对唾液腺苏木精-伊红染色的组织学切片进行形态学变化评估。
体重随年龄增加，而B组腮腺平均重量显著高于A组和C组。B组和C组唾液平均流速显著高于A组，B组和C组唾液平均pH值显著高于A组。唾液电解质和总蛋白分析表明，钠、钾和碳酸氢盐的平均水平随年龄显著增加，而钙、氯、磷酸盐和总蛋白的平均水平在各组间未显示出显著变化。
这些发现表明，衰老大鼠唾液腺形态出现不同变化，但功能未受损。
