Vidal-Peracho Concepción, Lucha-López Maria Orosia, Lucha-López Ana Carmen, Tricás-Moreno José Miguel, Estébanez-De Miguel Elena, Bernués-Vázquez Luis
Specialty Medical Center Grande Covián, SALUD, Avda. Alcalde Caballero, 196, 50014 Zaragoza, Spain ; Physiotherapy Research Unit, University of Zaragoza, C/Domingo Miral s/n, 50009 Zaragoza, Spain.
Faculty of Health Sciences, Physiotherapy Research Unit, University of Zaragoza, C/Domingo Miral s/n, 50009 Zaragoza, Spain.
Diabetol Metab Syndr. 2014 Dec 6;6:135. doi: 10.1186/1758-5996-6-135. eCollection 2014.
Ottawa Charter defined health as a resource for everyday life and as an important dimension of health related quality of life (HRqol). Diabetes and obesity have repeatedly been shown as diseases that diminish health status and HRqol. The aim of this study was to measure health status and HRqol in a Spanish sample of obese patients with type 2 diabetes at cardiovascular risk and analyze behavioural, biological and social determinants of health.
Outpatients from external specialized clinic in Endocrinology were evaluated.
sex, age, family history, employment status, comorbidities, pain, lifestyle habits, anthropometrics, blood pressure, blood analysis and HRqol with COOP/WONCA questionnaire (7 dimensions).
univariate, bivariate, multivariate and comparative analysis.
Mean age was 59.1 ± 7.6 [95%IC: 56.6-61.6], 74% were women and 63.2% were physically active. WONCA values were; summary index (SI): 18.7 ± 4 [95%IC: 17.3-20] (maximum 35); physical fitness: 3.3 ± 1, feelings: 2.3 ± 1.1, social activities: 1.5 ± 1, daily activities: 2.1 ± 1.2, change in health: 2.7 ± 0.9, overall health: 3.6 ± 0.7 and pain: 3.5 ± 1.2 (maximum 5). High fibrinogen values (339.3 ± 85.8 [95%IC: 309.8-368.8]) negatively influenced pain visual analogic scale (p = 0.029). Physically active patients (63.2%) had better values in daily activities dimension (p = 0.025). More than the half of the sample (51.5%) reported a good quality of sleep, but the pain worsened it (p = 0.040). High BMI values (34.8 ± 5.8 [95%IC: 32.9-36.7]) harmed the COOP-WONCA SI (p = 0.009). High glycated hemoglobin (HbA1c) values (6.8 ± 1.3 [95%IC: 6.3-7.2]) had a negative impact on COOP-WONCA SI (p = 0.018). Nor tailored diet (15.8%) or being employed (18.4%) influenced the HRqol. The regression that best models COOP-WONCA SI was adjusted for BMI and HbA1c. SI = 3.509 + 0.335BMI +0.330HbA1c.
HRqol was worse than in general population, but better than in previous studies of diabetes patients, without differences by sex or age, though feelings, daily activities and pain dimensions scored worse than in these studies. Higher levels of HbA1c, obesity and procoagulative state had a negative impact in these last dimensions. Pain impaired quality of sleep and physical activity had a positive impact in daily activities. BMI and HbA1c modeled the HRqol.
《渥太华宪章》将健康定义为日常生活的一种资源以及健康相关生活质量(HRqol)的一个重要维度。糖尿病和肥胖症一再被证明是会降低健康状况和HRqol的疾病。本研究的目的是测量西班牙一组有心血管疾病风险的2型糖尿病肥胖患者的健康状况和HRqol,并分析健康的行为、生物学和社会决定因素。
对来自外部内分泌专科诊所的门诊患者进行评估。
性别、年龄、家族病史、就业状况、合并症、疼痛、生活方式习惯、人体测量学指标、血压、血液分析以及使用COOP/WONCA问卷(7个维度)评估HRqol。
单变量、双变量、多变量和对比分析。
平均年龄为59.1±7.6岁[95%置信区间:56.6 - 61.6],74%为女性,63.2%身体活动活跃。WONCA值如下:综合指数(SI):18.7±4[95%置信区间:17.3 - 20](最大值35);身体健康:3.3±1,情感:2.3±1.1,社交活动:1.5±1,日常活动:2.1±1.2,健康变化:2.7±0.9,总体健康:3.6±0.7,疼痛:3.5±1.2(最大值5)。高纤维蛋白原值(339.3±85.8[95%置信区间:309.8 - 368.8])对疼痛视觉模拟量表有负面影响(p = 0.029)。身体活动活跃的患者(63.2%)在日常活动维度得分更高(p = 0.025)。超过一半的样本(51.5%)报告睡眠质量良好,但疼痛会使其恶化(p = 0.040)。高BMI值(34.8±5.8[95%置信区间:32.9 - 36.7])对COOP - WONCA综合指数有损害(p = 0.009)。高糖化血红蛋白(HbA1c)值(6.8±1.3[95%置信区间:6.3 - 7.2])对COOP - WONCA综合指数有负面影响(p = 0.018)。无论是定制饮食(15.8%)还是就业状况(18.4%)都未对HRqol产生影响。对COOP - WONCA综合指数拟合效果最佳的回归模型对BMI和HbA1c进行了校正。SI = 3.509 + 0.335BMI + 0.330HbA1c。
HRqol比一般人群差,但优于先前对糖尿病患者的研究,不存在性别或年龄差异,不过情感、日常活动和疼痛维度的得分比这些研究中的情况更差。较高水平的HbA1c、肥胖和促凝状态对这些最后维度有负面影响。疼痛会损害睡眠质量,而身体活动对日常活动有积极影响。BMI和HbA1c可模拟HRqol。