相似文献
1
X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine.
Nat Struct Mol Biol. 2015 Jun;22(6):506-508. doi: 10.1038/nsmb.3029. Epub 2015 May 11.
2
Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature. 2015 May 21;521(7552):322-7. doi: 10.1038/nature14431. Epub 2015 May 11.
3
X-ray structure of dopamine transporter elucidates antidepressant mechanism.
Nature. 2013 Nov 7;503(7474):85-90. doi: 10.1038/nature12533. Epub 2013 Sep 15.
4
Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site.
J Neurochem. 2024 Sep;168(9):2043-2055. doi: 10.1111/jnc.16179. Epub 2024 Jul 15.
5
Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (Prozac).
Mol Pharmacol. 2014 May;85(5):703-14. doi: 10.1124/mol.113.091249. Epub 2014 Feb 10.
6
Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart.
Nucl Med Biol. 2008 Feb;35(2):213-8. doi: 10.1016/j.nucmedbio.2007.11.006.
7
Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters.
Nat Commun. 2021 Apr 13;12(1):2199. doi: 10.1038/s41467-021-22385-9.
8
Interactions of antidepressants with the serotonin transporter: a contemporary molecular analysis.
Eur J Pharmacol. 2003 Oct 31;479(1-3):53-63. doi: 10.1016/j.ejphar.2003.08.056.
9
Structure Modeling of the Norepinephrine Transporter.
Biomolecules. 2020 Jan 7;10(1):102. doi: 10.3390/biom10010102.
10
Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.
J Med Chem. 2003 Dec 4;46(25):5512-32. doi: 10.1021/jm0309349.
引用本文的文献
1
Generation of Conformation-Specific Monoclonal Antibodies for Integral Membrane Proteins.
Curr Protoc. 2025 May;5(5):e70142. doi: 10.1002/cpz1.70142.
2
Monoamine signaling and neuroinflammation: mechanistic connections and implications for neuropsychiatric disorders.
Front Immunol. 2025 Apr 28;16:1543730. doi: 10.3389/fimmu.2025.1543730. eCollection 2025.
3
Revealing the location and dynamics of a concealed binding site in the dopamine transporter.
Nat Commun. 2025 May 6;16(1):4197. doi: 10.1038/s41467-025-59511-w.
4
Balancing Therapeutic Efficacy and Safety of MDMA and Novel MDXX Analogues as Novel Treatments for Autism Spectrum Disorder.
Psychedelic Med (New Rochelle). 2023 Sep 13;1(3):166-185. doi: 10.1089/psymed.2023.0023. eCollection 2023 Sep.
5
Uncovering the Elusive Structures and Mechanisms of Prevalent Antidepressants.
Adv Ther (Weinh). 2024 Sep;7(9). doi: 10.1002/adtp.202400117. Epub 2024 Jul 31.
6
Mechanistic insights of substrate transport and inhibitor binding revealed by high-resolution structures of human norepinephrine transporter.
Cell Res. 2024 Nov;34(11):810-813. doi: 10.1038/s41422-024-01024-0. Epub 2024 Sep 2.
7
Structure of the human dopamine transporter and mechanisms of inhibition.
Nature. 2024 Aug;632(8025):672-677. doi: 10.1038/s41586-024-07739-9. Epub 2024 Aug 7.
8
Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature. 2024 Aug;632(8026):921-929. doi: 10.1038/s41586-024-07719-z. Epub 2024 Jul 24.
9
The Structural Basis of the Activity Cliff in Modafinil-Based Dopamine Transporter Inhibitors.
Biomolecules. 2024 Jun 17;14(6):713. doi: 10.3390/biom14060713.
10
Allosteric modulation of serotonin and dopamine transporters: New insights from computations and experiments.
Curr Res Physiol. 2024 Mar 15;7:100125. doi: 10.1016/j.crphys.2024.100125. eCollection 2024.
本文引用的文献
1
Processing of X-ray diffraction data collected in oscillation mode.
Methods Enzymol. 1997;276:307-26. doi: 10.1016/S0076-6879(97)76066-X.
2
Screening and large-scale expression of membrane proteins in mammalian cells for structural studies.
Nat Protoc. 2014 Nov;9(11):2574-85. doi: 10.1038/nprot.2014.173. Epub 2014 Oct 9.
3
Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature. 2013 Nov 7;503(7474):141-5. doi: 10.1038/nature12648. Epub 2013 Oct 13.
4
X-ray structure of dopamine transporter elucidates antidepressant mechanism.
Nature. 2013 Nov 7;503(7474):85-90. doi: 10.1038/nature12533. Epub 2013 Sep 15.
5
Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket.
J Biol Chem. 2012 Dec 21;287(52):43694-707. doi: 10.1074/jbc.M112.342212. Epub 2012 Oct 19.
6
Towards automated crystallographic structure refinement with phenix.refine.
Acta Crystallogr D Biol Crystallogr. 2012 Apr;68(Pt 4):352-67. doi: 10.1107/S0907444912001308. Epub 2012 Mar 16.
7
SLC6 neurotransmitter transporters: structure, function, and regulation.
Pharmacol Rev. 2011 Sep;63(3):585-640. doi: 10.1124/pr.108.000869. Epub 2011 Jul 13.
8
Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site.
Nature. 2010 Dec 23;468(7327):1129-32. doi: 10.1038/nature09581.
9
Estimation of binding rate constants using a simultaneous mixed-effects method: application to monoamine transporter reuptake inhibitor reboxetine.
Br J Pharmacol. 2010 May;160(2):389-98. doi: 10.1111/j.1476-5381.2010.00719.x.
10
XDS.
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32. doi: 10.1107/S0907444909047337. Epub 2010 Jan 22.
Zotero 插件