人去甲肾上腺素转运体高分辨率结构揭示的底物转运和抑制剂结合的机制见解 - Suppr

Mechanistic insights of substrate transport and inhibitor binding revealed by high-resolution structures of human norepinephrine transporter.

作者信息

Song Ailong, Wu Xudong

机构信息

Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.

Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.

出版信息

Cell Res. 2024 Nov;34(11):810-813. doi: 10.1038/s41422-024-01024-0. Epub 2024 Sep 2.

DOI:10.1038/s41422-024-01024-0

PMID:39223283

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11528112/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427c/11528112/ffb3089072b0/41422_2024_1024_Fig1_HTML.jpg

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Mechanistic insights of substrate transport and inhibitor binding revealed by high-resolution structures of human norepinephrine transporter.人去甲肾上腺素转运体高分辨率结构揭示的底物转运和抑制剂结合的机制见解

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Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters.神经递质转运体中去甲肾上腺素识别和转运抑制的结构基础。

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Mechanistic insights of substrate transport and inhibitor binding revealed by high-resolution structures of human norepinephrine transporter.

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