Brugnano Jamie, Ward Brian C, Panitch Alyssa
Biomol Concepts. 2010 Aug 1;1(2):109-16. doi: 10.1515/bmc.2010.016.
Cell penetrating peptides (CPPs) have been successful in delivering cargo into many different cell types and are an important alternative to other methods of permeation that might damage the integrity of the cell membrane. The traditional view of CPPs is that they are inert molecules that can be successfully used to deliver many cargos intracellularly. The goal of this review is to challenge this traditional understanding of CPPs. Recent literature has demonstrated that CPPs themselves can convey biological activity, including the alteration of gene expression and inhibition of protein kinases and proteolytic activity. Further characterization of CPPs is required to determine the extent of this activity. Research into the use of CPPs for intracellular delivery should continue with investigators being aware of these recent results.
细胞穿透肽（CPPs）已成功地将货物递送至多种不同的细胞类型中，并且是可能会破坏细胞膜完整性的其他渗透方法的重要替代方案。对CPPs的传统看法是，它们是惰性分子，可以成功地用于在细胞内递送多种货物。本综述的目的是挑战对CPPs的这种传统理解。最近的文献表明，CPPs本身可以传达生物活性，包括基因表达的改变以及蛋白激酶和蛋白水解活性的抑制。需要对CPPs进行进一步表征以确定这种活性的程度。对于将CPPs用于细胞内递送的研究应继续进行，研究人员应了解这些最新结果。
