运动训练可改变正常小鼠和糖尿病小鼠的肠道微生物群。
Exercise training modifies gut microbiota in normal and diabetic mice.
作者信息
Lambert Jennifer E, Myslicki Jason P, Bomhof Marc R, Belke Darrell D, Shearer Jane, Reimer Raylene A
机构信息
a Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada.
b Department of Biochemistry and Molecular Biology, Cumming School of Medicine; University of Calgary, Calgary, AB T2N 4N1, Canada.
出版信息
Appl Physiol Nutr Metab. 2015 Jul;40(7):749-52. doi: 10.1139/apnm-2014-0452. Epub 2015 Feb 18.
Cecal microbiota from type 2 diabetic (db/db) and control (db/(+)) mice was obtained following 6 weeks of sedentary or exercise activity. qPCR analysis revealed a main effect of exercise, with greater abundance of select Firmicutes species and lower Bacteroides/Prevotella spp. in both normal and diabetic exercised mice compared with sedentary counterparts. Conversely, Bifidobacterium spp. was greater in exercised normal but not diabetic mice (exercise × diabetes interaction). How exercise influences gut microbiota requires further investigation.
在久坐或进行6周运动后，获取了2型糖尿病（db/db）小鼠和对照（db/(+)）小鼠的盲肠微生物群。定量聚合酶链反应（qPCR）分析显示运动有主要作用，与久坐的小鼠相比，正常和糖尿病运动小鼠中特定厚壁菌门物种丰度更高，拟杆菌属/普氏菌属物种丰度更低。相反，双歧杆菌属在运动的正常小鼠中丰度更高，但在糖尿病小鼠中并非如此（运动×糖尿病相互作用）。运动如何影响肠道微生物群需要进一步研究。
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