College of Exercise and Health, Shenyang Sport University, Shenyang, Liaoning, P. R. China.
Department of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, P. R. China.
Gut Microbes. 2024 Jan-Dec;16(1):2404141. doi: 10.1080/19490976.2024.2404141. Epub 2024 Sep 21.
Cardiometabolic diseases (CMDs), encompassing cardiovascular and metabolic dysfunctions, characterized by insulin resistance, dyslipidemia, hepatic steatosis, and inflammation, have been identified with boosting morbidity and mortality due to the dearth of efficacious therapeutic interventions. In recent years, studies have shown that variations in gut microbiota and its own metabolites can influence the occurrence of CMDs. Intriguingly, the composition and function of the gut microbiota are susceptible to exercise patterns, thus affecting inflammatory, immune, and metabolic responses within the host. In this review, we introduce the key mechanisms of intestinal microecology involved in the onset and development of CMDs, discuss the relationship between exercise and intestinal microecology, and then analyze the role of intestinal microecology in the beneficial effects of exercise on CMDs, aiming at elucidating the gut-heart axis mechanisms of exercise mediated protective effect on CMDs, building avenues for the application of exercise in the management of CMDs.
心血管代谢疾病（CMD）涵盖了心血管和代谢功能障碍，其特征是胰岛素抵抗、血脂异常、肝脂肪变性和炎症，由于缺乏有效的治疗干预措施，发病率和死亡率不断上升。近年来的研究表明，肠道微生物群及其自身代谢物的变化会影响 CMD 的发生。有趣的是，肠道微生物群的组成和功能易受运动模式的影响，从而影响宿主的炎症、免疫和代谢反应。在这篇综述中，我们介绍了肠道微生态在 CMD 发生和发展中涉及的关键机制，讨论了运动与肠道微生态的关系，然后分析了肠道微生态在运动对 CMD 有益作用中的作用，旨在阐明运动对 CMD 的保护作用的肠道-心脏轴机制，为运动在 CMD 管理中的应用开辟途径。
