儿童松果体肿瘤的扩散特征。
Diffusion characteristics of pediatric pineal tumors.
作者信息
Choudhri Asim F, Whitehead Matthew T, Siddiqui Adeel, Klimo Paul, Boop Frederick A
机构信息
Department of Radiology, University of Tennessee Health Science Center, USA Department of Neurosurgery, University of Tennessee Health Science Center, USA Department of Ophthalmology, University of Tennessee Health Science Center, USA Le Bonheur Neuroscience Institute, Le Bonheur Children's Hospital, USA
Department of Radiology, University of Tennessee Health Science Center, USA Le Bonheur Neuroscience Institute, Le Bonheur Children's Hospital, USA Department of Radiology, Children's National Medical Center, USA.
出版信息
Neuroradiol J. 2015 Apr;28(2):209-16. doi: 10.1177/1971400915581741. Epub 2015 May 11.
BACKGROUND
Diffusion weighted imaging (DWI) has been shown to be helpful in characterizing tumor cellularity, and predicting histology. Several works have evaluated this technique for pineal tumors; however studies to date have not focused on pediatric pineal tumors.
OBJECTIVE
We evaluated the diffusion characteristics of pediatric pineal tumors to confirm if patterns seen in studies using mixed pediatric and adult populations remain valid.
MATERIALS AND METHODS
This retrospective study was performed after Institutional Review Board approval. We retrospectively evaluated all patients 18 years of age and younger with pineal tumors from a single institution where preoperative diffusion weighted imaging as well as histologic characterization was available.
RESULTS
Twenty patients (13 male, 7 female) with pineal tumors were identified: seven with pineoblastoma, four with Primitive Neuroectodermal Tumor (PNET), two with other pineal tumors, and seven with germ cell tumors including two germinomas, three teratomas, and one mixed germinoma-teratoma. The mean apparent diffusion coefficient (ADC) values in pineoblastoma (544 ± 65 × 10⁻⁶ mm²/s) and pineoblastoma/PNET (595 ± 144 × 10⁻⁶ mm²/s) was lower than that of the germ cell tumors (1284 ± 334 × 10⁻⁶ mm²/s; p < 0.0001 vs pineoblastoma). One highly cellular germinoma had an ADC value of 694 × 10⁻⁶ mm²/s.
CONCLUSION
ADC values can aid in differentiation of pineoblastoma/PNET from germ cell tumors in a population of children with pineal masses.
背景
扩散加权成像（DWI）已被证明有助于描述肿瘤细胞构成并预测组织学类型。已有多项研究评估了该技术在松果体肿瘤中的应用；然而，迄今为止的研究尚未聚焦于儿童松果体肿瘤。
目的
我们评估了儿童松果体肿瘤的扩散特征，以确定在混合了儿童和成人的研究中所观察到的模式是否仍然有效。
材料与方法
本回顾性研究在获得机构审查委员会批准后进行。我们回顾性评估了来自单一机构的所有18岁及以下患有松果体肿瘤的患者，这些患者均有术前扩散加权成像以及组织学特征。
结果
共确定了20例松果体肿瘤患者（13例男性，7例女性）：7例松果体母细胞瘤，4例原始神经外胚层肿瘤（PNET），2例其他松果体肿瘤，7例生殖细胞肿瘤，其中包括2例生殖细胞瘤、3例畸胎瘤和1例混合性生殖细胞瘤 - 畸胎瘤。松果体母细胞瘤（（544 ± 65 × 10⁻⁶ mm²/s））和松果体母细胞瘤/PNET（595 ± 144 × 10⁻⁶ mm²/s）的平均表观扩散系数（ADC）值低于生殖细胞肿瘤（1284 ± 334 × 10⁻⁶ mm²/s；与松果体母细胞瘤相比，p < 0.0001）。1例细胞密集的生殖细胞瘤的ADC值为694 × 10⁻⁶ mm²/s。
结论
ADC值有助于在患有松果体肿块的儿童群体中将松果体母细胞瘤/PNET与生殖细胞肿瘤区分开来。
Zotero 插件