Dahlstrand C, Theodorsson E, Dahlström A, Ahlman H
Department of Surgery, University of Gothenburg, Stockholm, Sweden.
Acta Physiol Scand. 1989 Nov;137(3):375-8. doi: 10.1111/j.1748-1716.1989.tb08766.x.
Regional administration of VIP elicited a dose-dependent relaxation of the feline sphincter of Oddi and gall-bladder. Relaxatory motor responses of these regions at efferent electrical stimulation of the vagal nerves were unmasked after atropine (resistant to propranolol but sensitive to hexamethonium). These findings in combination with the presence of a rich VIP-ergic innervation, including intrinsic VIP neurons, have made VIP a tentative post-ganglionic non-adrenergic, non-cholinergic neurotransmitter to these regions. The relaxatory motor responses elicited by VIP or vagal activation were selectively antagonized using regional administration of specific VIP antisera in support of this hypothesis.
向特定区域注射血管活性肠肽（VIP）可引起猫奥迪括约肌和胆囊出现剂量依赖性舒张。在使用阿托品后（对普萘洛尔有抗性但对六甲铵敏感），迷走神经传出电刺激时这些区域的舒张性运动反应得以显现。这些发现，再加上丰富的VIP能神经支配的存在，包括内在的VIP神经元，使得VIP成为这些区域一种可能的节后非肾上腺素能、非胆碱能神经递质。通过在特定区域注射特异性VIP抗血清，可选择性拮抗由VIP或迷走神经激活引起的舒张性运动反应，从而支持了这一假说。
