Department of Urology, University Medical Centre Utrecht, Room C.04.236, Heidelberglaan 100, P.O. Box 85500, 3584 CX, Utrecht, Netherlands.
Department of Paediatric Urology Paediatric Renal Centre, Department of Paediatric Urology, University Children's Hospital, UMCU, P.O. Box 85090, 3508 AB, Utrecht, Netherlands.
Nat Rev Urol. 2015 Jun;12(6):331-9. doi: 10.1038/nrurol.2015.99. Epub 2015 May 12.
The incidence of newborns with spinal dysraphism is diminishing worldwide, although survival of individuals with this condition into adulthood continues to improve. The number of adults with spinal dysraphism will, therefore, increase in the coming years, which will pose new challenges in patient management. Urological manifestations of spinal dysraphism can include increased risks of urinary incontinence, urinary tract infection, urinary calculi, sexual dysfunction, end-stage renal disease and iatrogenic metabolic disturbances; however, the severity and incidence of these symptoms varies substantially between patients. Owing to the presence of multiple comorbidities, treatment and follow-up protocols often have to be adapted to best suit the needs of specific patients. Authors describe bladder and kidney function and long-term complications of treatments initiated in childhood, as well as the potential for improvements in quality of life through better follow-up schedules and future developments.
全球范围内,新生儿脊柱裂的发病率正在下降,尽管此类患者的生存状况持续改善,直至成年。因此,未来数年,脊柱裂患者人数将会增加,这将给患者管理带来新的挑战。脊柱裂的泌尿系统表现包括尿失禁、尿路感染、尿路结石、性功能障碍、终末期肾病和医源性代谢紊乱的风险增加;然而,这些症状的严重程度和发生率在患者之间存在显著差异。由于存在多种合并症,治疗和随访方案通常必须进行调整,以最好地满足特定患者的需求。作者描述了儿童时期开始的治疗对膀胱和肾脏功能的影响以及长期并发症,以及通过更好的随访计划和未来发展提高生活质量的潜力。