Moyer C L, Holly R G, Amsterdam E A, Atkinson R L
Department of Physical Education, University of California, Davis.
Am J Clin Nutr. 1989 Dec;50(6):1324-7. doi: 10.1093/ajcn/50.6.1324.
To assess the safety of very-low-calorie diets (VLCDs), stress tests known to induce arrhythmias in susceptible patients were performed in 24 obese women on a VLCD (660-720 kcal/d) for 6 wk. Half of the subjects had diet only (DO) and half underwent supervised exercise (DE) four times weekly. Five control subjects ate a balanced, moderately low-calorie diet (approximately 1400 kcal/d). Stress tests included maximal and submaximal (85%) exercise, psychological stress, and isometric handgrip tests, all with constant electrocardiogram (ECG) monitoring. Twenty-four-hour Holter monitors at weeks 0 and 6 and weekly resting ECGs were obtained. DO and DE lost similar amounts of weight. There were no changes in QT intervals or in voltage or width of the QRS complex on resting ECG and no arrhythmias on Holter monitoring. These data support the safety of VLCDs containing greater than or equal to 650 kcal/d and adequate amounts of high-quality protein, vitamins, and minerals for use for periods of at least 6 wk in normal, healthy obese women.
为评估极低热量饮食（VLCD）的安全性，对24名肥胖女性进行了已知会在易感患者中诱发心律失常的应激测试。这些女性接受了为期6周的VLCD（660 - 720千卡/天）。其中一半受试者仅进行饮食控制（DO），另一半每周接受4次有监督的运动（DE）。5名对照受试者食用均衡的适度低热量饮食（约1400千卡/天）。应激测试包括最大运动量和次最大运动量（85%）运动、心理应激和等长握力测试，所有测试均持续进行心电图（ECG）监测。在第0周和第6周进行了24小时动态心电图监测，并每周进行静息心电图检查。DO组和DE组减重情况相似。静息心电图上QT间期、QRS波群电压或宽度均无变化，动态心电图监测也未发现心律失常。这些数据支持了对于正常、健康的肥胖女性，每天热量摄入大于或等于650千卡且含有足够量优质蛋白质、维生素和矿物质的VLCD在至少6周时间内使用的安全性。
