Jacobsen L K, Kosten T R
Department of Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven 06519.
Am J Drug Alcohol Abuse. 1989;15(4):355-66. doi: 10.3109/00952998908992796.
Thirty seven consecutive applicants to methadone maintenance were assessed for depression and for level of opiate dependence using a 0.8-mg naloxone challenge. Nineteen of the applicants met DSM-III-R criteria for current major depression. At 3-month follow-up, high naloxone challenge test (NCT) scores at intake (high levels of opiate addiction) were found to predict poor program retention and elevated symptoms of depression at follow-up. Reports of heavy current drug use at intake were also associated with poor program retention and with high frequencies of positive urine screens for illicit substances during treatment. Level of addiction and reported amount of drug use at intake independently predicted program retention with a multiple correlation of 0.46 (P less than .01). Although NCT predicted depression at follow-up, depression at intake did not significantly predict treatment outcome, and NCT score predicted outcome independently of psychopathology.
对37名连续申请美沙酮维持治疗的患者，使用0.8毫克纳洛酮激发试验评估其抑郁情况和阿片类药物依赖程度。19名申请者符合当前重度抑郁的DSM-III-R标准。在3个月的随访中，发现入组时纳洛酮激发试验（NCT）高分（阿片类药物成瘾程度高）可预测较差的项目留存率以及随访时抑郁症状加重。入组时大量当前吸毒报告也与较差的项目留存率以及治疗期间非法物质尿筛查阳性高频率相关。入组时的成瘾程度和报告的吸毒量独立预测项目留存率，多重相关系数为0.46（P小于0.01）。尽管NCT可预测随访时的抑郁，但入组时的抑郁并不能显著预测治疗结果，且NCT分数独立于精神病理学预测结果。
