Rounsaville B J, Weissman M M, Crits-Christoph K, Wilber C, Kleber H
Arch Gen Psychiatry. 1982 Feb;39(2):151-6. doi: 10.1001/archpsyc.1982.04290020021004.
Evaluations of diagnosis and symptoms of depression were undertaken in 157 opiate addicts at entrance to a multimodality drug treatment program and six months later. While 17% were having an episode of major depression (defined by Research Diagnostic Criteria) and 60% had at least mildly elevated depressive symptoms at entrance to treatment, substantial improvement was noted at the six-month reevaluation, with the rates of major depression and elevated symptoms dropping to 12% and 31%, respectively. Symptomatic improvement, although related to retention in treatment, was not the result of specific antidepressant pharmacotherapy and did not differ across treatment modalities. Starting treatment during a major or minor depressive episode was predictive of poorer outcome in the areas of illicit drug use and psychological symptoms, but unrelated to the areas of occupational functioning, legal problems, and program retention.
在157名阿片类药物成瘾者进入多模式药物治疗项目时及六个月后，对其抑郁症的诊断和症状进行了评估。在进入治疗时，17%的人患有重度抑郁症发作（根据研究诊断标准定义），60%的人至少有轻度抑郁症状加重，而在六个月的重新评估中发现有显著改善，重度抑郁症和症状加重的比例分别降至12%和31%。症状改善虽然与坚持治疗有关，但并非特定抗抑郁药物治疗的结果，且在不同治疗模式之间没有差异。在重度或轻度抑郁发作期间开始治疗可预测在非法药物使用和心理症状方面的较差结果，但与职业功能、法律问题和项目留存方面无关。
