Katelaris Nikolas Christopher, Bolton Damien Michael, Weerakoon Mahesha, Toner Liam, Katelaris Phillip Mark, Lawrentschuk Nathan
Department of Surgery, Austin Hospital, University of Melbourne, Melbourne, VIC, Australia.
Sydney Adventist Hospital, Sydney, NSW, Australia.
Korean J Urol. 2015 May;56(5):337-45. doi: 10.4111/kju.2015.56.5.337. Epub 2015 Apr 6.
The purpose of this review was to evaluate the current role of multiparametric magnetic resonance imaging (mp-MRI) in the management of prostate cancer (PC). The diagnosis of PC remains controversial owing to overdetection of indolent disease, which leads to overtreatment and subsequent patient harm. mp-MRI has the potential to equilibrate the imbalance between detection and treatment. The limitation of the data for analysis with this new technology is problematic, however. This issue has been compounded by a paradigm shift in clinical practice aimed at utilizing this modality, which has been rolled out in an ad hoc fashion often with commercial motivation. Despite a growing body of literature, pertinent clinical questions remain. For example, can mp-MRI be calibrated to reliably detect biologically significant disease? As with any new technology, objective evaluation of the clinical applications of mp-MRI is essential. The focus of this review was on the evaluation of mp-MRI of the prostate with respect to clinical utility.
本综述的目的是评估多参数磁共振成像（mp-MRI）在前列腺癌（PC）管理中的当前作用。由于惰性疾病的过度检测，PC的诊断仍存在争议，这会导致过度治疗并对患者造成后续伤害。mp-MRI有可能平衡检测与治疗之间的失衡。然而，使用这项新技术进行分析的数据存在局限性，这是个问题。临床实践中旨在利用这种检查方式的范式转变使这个问题更加复杂，这种转变往往是出于商业动机以临时的方式推行的。尽管相关文献越来越多，但仍存在一些相关的临床问题。例如，mp-MRI能否经过校准以可靠地检测出具有生物学意义的疾病？与任何新技术一样，对mp-MRI临床应用进行客观评估至关重要。本综述的重点是评估前列腺mp-MRI的临床实用性。
