Ibanez H E, Ibanez M A
Department of Medicine, San Juan Veterans Administration Hospital, Puerto Rico.
Am J Med Sci. 1989 Dec;298(6):407-9. doi: 10.1097/00000441-198912000-00009.
The clinical and histopathological features and the therapeutic response of a pustular eruption occurring in a homosexual man with Acquired Immune Deficiency Syndrome (AIDS) is reported. The rare cutaneous presentation consisted of mostly circumscribed, tender, tense pustules, associated with erythema, confined to the face and neck. Biopsy of these lesions revealed intracellular round to oval bodies surrounded by a clear space, consistent with Histoplasma capsulatum. Prompt resolution was observed after initiation of amphotericin B therapy. Clinicians are alerted to the occurrence of exotic presentations of this entity and emphasis is given to the need for skin biopsy and culture to avoid delay in diagnosis and failure to initiate appropriate therapy.
报告了一名患有获得性免疫缺陷综合征（艾滋病）的同性恋男子出现的脓疱性皮疹的临床、组织病理学特征及治疗反应。这种罕见的皮肤表现主要由大多为边界清楚、触痛、紧张的脓疱组成，伴有红斑，局限于面部和颈部。对这些皮损进行活检发现细胞内有圆形至椭圆形小体，周围有透明间隙，符合荚膜组织胞浆菌。开始两性霉素B治疗后观察到皮疹迅速消退。提醒临床医生注意该疾病的特殊表现，并强调进行皮肤活检和培养的必要性，以避免诊断延误和未能启动适当治疗。
