白刺提取物及其成分异鼠李素对β-淀粉样蛋白诱导的细胞毒性和β-淀粉样蛋白聚集的保护作用。
Protective effects of Nitraria retusa extract and its constituent isorhamnetin against amyloid β-induced cytotoxicity and amyloid β aggregation.
作者信息
Iida Akihisa, Usui Takeo, Zar Kalai Feten, Han Junkyu, Isoda Hiroko, Nagumo Yoko
机构信息
a Graduate School of Life and Environmental Sciences , University of Tsukuba , Tsukuba , Japan.
出版信息
Biosci Biotechnol Biochem. 2015;79(9):1548-51. doi: 10.1080/09168451.2015.1027655. Epub 2015 May 12.
Nitraria retusa is a halophyte species that is distributed in North Africa and used as a traditional medicinal plant. In this study, N. retusa ethanol extract and its constituent isorhamnetin (IRA) protected against amyloid β (Aβ)-induced cytotoxicity in human neuroblastoma SH-SY5Y cells. An in vitro Aβ aggregation assay suggested that IRA destabilizes Aβ fibrils.
白刺是一种分布于北非的盐生植物，被用作传统药用植物。在本研究中，白刺乙醇提取物及其成分异鼠李素（IRA）可保护人神经母细胞瘤SH-SY5Y细胞免受淀粉样β（Aβ）诱导的细胞毒性。体外Aβ聚集试验表明，IRA可使Aβ纤维不稳定。
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