Peverill Roger E
Monash Cardiovascular Research Centre, MonashHeart and Department of Medicine (School of Clinical Sciences at Monash Medical Centre), Monash University and Monash Health, Clayton, Victoria, Australia.
Int J Cardiol. 2015 Jul 15;191:110-3. doi: 10.1016/j.ijcard.2015.04.254. Epub 2015 May 1.
The use of the terms "left ventricular filling pressure" and "left ventricular filling pressures" is widespread in the cardiology literature, but the meanings ascribed to these terms have not been consistent. Left ventricular end-diastolic pressure (LVEDP) and mean left atrial pressure (LAP) cannot be used interchangeably as they will often differ in magnitude in the presence of cardiac disease and they also have different clinical significance. LVEDP is the best pressure to use when considering left ventricular function, whereas mean LAP is the most relevant pressure when considering the tendency to pulmonary congestion. The mean LAP is also the most relevant pressure for determining whether pulmonary hypertension has a left heart (post-capillary) component. If only a left ventricular pressure tracing is available then a technique to measure the mean left ventricular diastolic pressure is the best option for estimating the mean LAP. If only right heart pressures are available then the pulmonary artery end-diastolic pressure will provide a reasonable estimate of LVEDP, but only when the heart and pulmonary circulation are normal. If there is mitral valve disease, left ventricular disease or pulmonary hypertension the LVEDP cannot be estimated from right heart pressures. The problem of the ambiguity of "filling pressure (s)" is readily solved by the abandonment of this term and the use of either LVEDP or mean LAP as appropriate.
“左心室充盈压”和“左心室充盈压们”这两个术语在心脏病学文献中广泛使用,但赋予这些术语的含义并不一致。左心室舒张末期压力(LVEDP)和左心房平均压力(LAP)不能互换使用,因为在存在心脏疾病时它们的大小常常不同,而且它们也具有不同的临床意义。在考虑左心室功能时,LVEDP是最合适的压力指标,而在考虑肺充血倾向时,平均LAP是最相关的压力指标。平均LAP也是确定肺动脉高压是否具有左心(毛细血管后)成分时最相关的压力指标。如果仅能获得左心室压力曲线,那么测量左心室舒张期平均压力的技术是估计平均LAP的最佳选择。如果仅能获得右心压力,那么肺动脉舒张末期压力将能合理地估计LVEDP,但这仅在心脏和肺循环正常时才成立。如果存在二尖瓣疾病、左心室疾病或肺动脉高压,则无法根据右心压力来估计LVEDP。通过摒弃“充盈压”这一术语,并根据情况适当使用LVEDP或平均LAP,“充盈压”的模糊性问题很容易得到解决。