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非体外循环下经胸房间隔缺损和室间隔缺损封堵术

Transthoracic closure of atrial septal defect and ventricular septal defect without cardiopulmonary bypass.

作者信息

Wan L, Yu B-T, Wu Q-C, Zeng L, Wang Q, Tang J, Xu Q-R, Xu H, Wang W-J, Cao Y-P, Liu J-C

机构信息

Department of Cardiothoracic Surgery, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.

Department of Cardiothoracic Surgery, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China

出版信息

Genet Mol Res. 2015 Apr 22;14(2):3760-6. doi: 10.4238/2015.April.22.4.

Abstract

The minimally invasive surgical transthoracic occlusion of an atrial septal defect (ASD) or a ventricular septal defect (VSD) is an increasingly widespread alternative treatment for congenital heart disease. The aim of this study is to summarize our clinical experience with minimally invasive surgical transthoracic occlusion of ASD and VSD without cardiopulmonary bypass (CPB). Between April 2011 and October 2012, 27 patients with ASD and 95 patients with VSD (78 men and 44 women) were considered for minimally invasive surgical transthoracic occlusion without CPB. A small infrasternal incision (2.0-4.0 cm) was made under general anesthesia, under transesophageal echocardiography (TEE) guidance; the ASD and VSD were closed by using an appropriate occluder; and TEE was performed simultaneously to demonstrate the position of the device, any residual shunting, or encroachment on the atrioventricular valve, coronary sinus, or aortic valve. Successful transthoracic occlusion was performed in all 122 patients without complications. No complications such as third-degree atrioventricular block and residual shunting occurred after the procedures. The ventilation time was 2.2 ± 1.2 h, and the average length of hospital stay was 4.7 ± 1.7 days. All patients received aspirin at 3 mg·kg(-1)·day(-1) (maximum 100 mg/day) 24 h after the procedure. Minimally invasive surgical transthoracic occlusion without CPB is a new treatment that has many advantages such as causing little trauma, promoting quick recovery, having less complications, and avoiding radiation damage. However, the appropriate selection of patients is still key to improving the success rate of the operation.

摘要

微创经胸封堵房间隔缺损(ASD)或室间隔缺损(VSD)是先天性心脏病越来越广泛应用的替代治疗方法。本研究的目的是总结我们在非体外循环(CPB)下微创经胸封堵ASD和VSD的临床经验。2011年4月至2012年10月,27例ASD患者和95例VSD患者(78例男性和44例女性)被考虑行非CPB下微创经胸封堵术。在全身麻醉下,于食管超声心动图(TEE)引导下做一个小的胸骨下切口(2.0 - 4.0 cm);使用合适的封堵器关闭ASD和VSD;同时进行TEE以显示封堵器位置、有无残余分流或对房室瓣、冠状窦或主动脉瓣的侵犯情况。122例患者均成功进行了经胸封堵,无并发症发生。术后未出现三度房室传导阻滞和残余分流等并发症。通气时间为2.2±1.2小时,平均住院时间为4.7±1.7天。所有患者术后24小时接受阿司匹林治疗,剂量为3 mg·kg⁻¹·天⁻¹(最大剂量100 mg/天)。非CPB下微创经胸封堵术是一种新的治疗方法,具有创伤小、恢复快、并发症少、避免辐射损伤等诸多优点。然而,恰当选择患者仍是提高手术成功率的关键。

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