Xiong F, Tong Y, Li P, Huo T, Mao M
Department of Pediatrics, West China Second University Hospital, Sichuan University, China.
Laboratory of Early Developmental and Injuries, West China Institute of Woman and Children's Health, West China Second University Hospital, Sichuan University, China.
Genet Mol Res. 2015 Apr 27;14(2):3879-88. doi: 10.4238/2015.April.27.2.
We evaluated the relationship between total serum immunoglobulin E (IgE) levels and pregnancy outcome in a prospective cohort study focusing on fetal growth restriction (FGR). Sixty women with FGR and twenty with normal singleton pregnancy were enrolled during their third trimester. Infants were followed up for 6 months. Blood samples were obtained from pregnant women during the third trimester; cord blood samples were also taken. Six months after birth, blood samples were obtained from infants. Demographic and baseline characteristics were compared between groups. Birth weight, length and head circumference of neonates in the FGR group were lower than those in the control group. Total serum IgE level was significantly increased in third-trimester pregnant women with FGR compared with normal group (P < 0.05). However, this trend was not observed in the cord blood at birth or peripheral blood of 6-month-old infants. The prevalence of atopic eczema between the 2 groups was similar. Linear regression analysis revealed that the IgE level in the third trimester was negatively correlated with birth weight (P < 0.05). Higher serum IgE level in the cord blood was significantly associated with an increased risk of being small for gestational age (P < 0.05). In conclusion, IgE levels in the third trimester of pregnancy and cord blood are strongly related to birth outcomes of FGR.
在一项聚焦于胎儿生长受限（FGR）的前瞻性队列研究中，我们评估了血清总免疫球蛋白E（IgE）水平与妊娠结局之间的关系。在孕晚期，招募了60名患有FGR的女性和20名单胎妊娠正常的女性。对婴儿进行了6个月的随访。在孕晚期采集孕妇的血液样本；同时也采集脐带血样本。出生6个月后，采集婴儿的血液样本。比较了两组之间的人口统计学和基线特征。FGR组新生儿的出生体重、身长和头围均低于对照组。与正常组相比，FGR孕妇孕晚期的血清总IgE水平显著升高（P<0.05）。然而，在出生时的脐带血或6个月大婴儿的外周血中未观察到这种趋势。两组之间特应性皮炎的患病率相似。线性回归分析显示，孕晚期的IgE水平与出生体重呈负相关（P<0.05）。脐带血中较高的血清IgE水平与小于胎龄儿风险增加显著相关（P<0.05）。总之，孕期第三个月和脐带血中的IgE水平与FGR的出生结局密切相关。
