Hecker J F
Department of Physiology, University of New England, Armidale, N.S.W.
Anaesth Intensive Care. 1989 Nov;17(4):433-9. doi: 10.1177/0310057X8901700406.
A survey was done to compare the rates at which phlebitis and extravasation cause failure of intravenous infusions lasting more than 24 hours. Slightly more infusions failed due to phlebitis than to extravasation but extravasation did not occur earlier or later than phlebitis or differ significantly from it in frequency when different types of infusions were compared. Univariate life table analysis indicated that the co-infusion of blood, potassium or cephalosporin antibiotics slightly increased and that higher flow rates markedly increased failure, that infusions including continuous heparin and steroids had markedly decreased failure, and that failure was not significantly affected by other antibiotics or by differences in sex, age, location of infusion site or time of year. Multivariate analysis showed that the above differences were statistically significant only for infusion rate, heparin and steroids.
开展了一项调查，以比较静脉炎和药物外渗导致持续超过24小时的静脉输液失败的发生率。因静脉炎导致输液失败的情况略多于因药物外渗导致的，但在比较不同类型的输液时，药物外渗并不比静脉炎更早或更晚发生，且在频率上与静脉炎没有显著差异。单因素生存表分析表明，同时输注血液、钾或头孢菌素类抗生素会使失败率略有增加，而较高的流速会显著增加失败率，包括持续输注肝素和类固醇的输液失败率显著降低，而其他抗生素或性别、年龄、输液部位或一年中的时间差异对失败率没有显著影响。多因素分析表明，上述差异仅在输液速度、肝素和类固醇方面具有统计学意义。
