Remmel Liina, Tillmann Vallo, Mäestu Jarek, Purge Priit, Saar Meeli, Lätt Evelin, Maasalu Katre, Jürimäe Toivo, Jürimäe Jaak
Faculty of Exercise and Sport Sciences, University of Tartu, Tartu, Estonia.
Horm Res Paediatr. 2015;84(1):6-13. doi: 10.1159/000381623. Epub 2015 May 6.
BACKGROUND/AIMS: The role of ghrelin and peptide YY (PYY) in bone mineralization is not fully known. The aim of this study was to determine whether acylated and des-acyl ghrelin and PYY in addition to leptin are related to bone mineral density (BMD) in adolescent overweight boys (OWB) and normal-weight boys (NWB).
Fifty- five OWB (BMI >85th percentile) and 154 NWB (BMI <85th percentile) aged 12-16 years participated in this study. Fasting serum acylated and des-acyl ghrelin, PYY, leptin, testosterone levels, total body (TB) and lumbar spine (LS) bone mineral content (BMC), and BMD were measured. TB BMC for height and TB and LS bone mineral apparent density (BMAD) were calculated.
No differences were seen in acylated and des-acyl ghrelin or PYY levels, while the leptin levels were significantly higher in the OWB compared to the NWB. In the OWB, TB BMAD was positively correlated with acylated ghrelin and leptin, and TB BMC for height was positively correlated with PYY. In the OWB, the variability of TB BMD was determined by TB fat-free mass and des-acyl ghrelin, whereas the variability of TB BMAD was determined by leptin.
Des-acyl ghrelin and PYY are involved in the bone mineralization process in puberty, and the impact can vary between normal and overweight subjects.
背景/目的：胃饥饿素和肽YY（PYY）在骨矿化中的作用尚未完全明确。本研究旨在确定除瘦素外，酰基化和去酰基化胃饥饿素以及PYY是否与青少年超重男孩（OWB）和正常体重男孩（NWB）的骨密度（BMD）相关。
55名12至16岁的OWB（BMI>第85百分位数）和154名NWB（BMI<第85百分位数）参与了本研究。测量了空腹血清酰基化和去酰基化胃饥饿素、PYY、瘦素、睾酮水平、全身（TB）和腰椎（LS）骨矿物质含量（BMC）以及BMD。计算了身高对应的TB BMC以及TB和LS骨矿物质表观密度（BMAD）。
酰基化和去酰基化胃饥饿素或PYY水平未见差异，而OWB的瘦素水平显著高于NWB。在OWB中，TB BMAD与酰基化胃饥饿素和瘦素呈正相关，身高对应的TB BMC与PYY呈正相关。在OWB中，TB BMD的变异性由TB无脂肪量和去酰基化胃饥饿素决定，而TB BMAD的变异性由瘦素决定。
去酰基化胃饥饿素和PYY参与青春期骨矿化过程，且在正常和超重个体中的影响可能不同。
