Crankshaw D P, Karasawa F
University Department of Surgery, Royal Melbourne Hospital, Victoria.
Anaesth Intensive Care. 1989 Nov;17(4):496-9. doi: 10.1177/0310057X8901700418.
We have tabulated the series of steps in infusion rate required to maintain constant arterial levels of thiopentone and methohexitone. The tables are based on multiexponential equations for infusion rate, derived from plasma drug efflux studies. In each table an initial bolus is followed by nine steps in infusion rate over three hours. The tables provide rates suitable for delivery by a standard syringe pump to achieve and maintain an arterial concentration of 10 mg/l of thiopentone and 5 mg/l of methohexitone. Other desired drug concentrations can be derived from the table by simple multiplication.
我们已将维持硫喷妥钠和甲己炔巴比妥动脉血药浓度恒定所需的输注速率步骤制成表格。这些表格基于输注速率的多指数方程，该方程源自血浆药物流出研究。在每张表格中，先给予一次初始推注，随后在三小时内分九个步骤调整输注速率。这些表格提供的速率适用于通过标准注射泵给药，以达到并维持硫喷妥钠动脉血药浓度为10毫克/升和甲己炔巴比妥动脉血药浓度为5毫克/升。通过简单乘法运算，可从表格中得出其他所需的药物浓度。
