靶向前列腺癌干细胞的微小RNA
MicroRNAs targeting prostate cancer stem cells.
作者信息
Fang Yu-Xiang, Chang Yun-Li, Gao Wei-Qiang
机构信息
State Key Laboratory of Oncogenes and Related Genes, Renji-MedX Clinical Stem Cell Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
State Key Laboratory of Oncogenes and Related Genes, Renji-MedX Clinical Stem Cell Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China
出版信息
Exp Biol Med (Maywood). 2015 Aug;240(8):1071-8. doi: 10.1177/1535370215584935. Epub 2015 May 12.
Abstract
Prostate cancer is a frequently diagnosed cancer in males with high mortality in the world. As a heterogeneous tissue, the tumor mass contains a subpopulation that is called as cancer stem cells and displays stem-like properties such as self-renewal, epithelial-mesenchymal transition, metastasis, and drug resistance. Cancer stem cells have been identified in variant tumors and shown to be regulated by various molecules including microRNAs. MicroRNAs are a class of small non-coding RNAs, which can influence tumorigenesis via different mechanisms. In this review, we focus on the functions of microRNAs on regulating the stemness of prostate cancer stem cells with different mechanisms and propose the potential roles of microRNAs in prostate cancer therapy.
摘要
前列腺癌是一种在全球男性中经常被诊断出且死亡率很高的癌症。作为一种异质性组织，肿瘤块包含一个被称为癌症干细胞的亚群，该亚群表现出自我更新、上皮-间质转化、转移和耐药性等干细胞样特性。癌症干细胞已在多种肿瘤中被鉴定出来，并显示受包括微小RNA在内的各种分子调控。微小RNA是一类小的非编码RNA，可通过不同机制影响肿瘤发生。在本综述中，我们重点关注微小RNA通过不同机制调节前列腺癌干细胞干性的功能，并提出微小RNA在前列腺癌治疗中的潜在作用。
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本文引用的文献
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Int J Oncol. 2014 Jul;45(1):362-72. doi: 10.3892/ijo.2014.2413. Epub 2014 Apr 30.
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