Tesarova P, Cabinakova M, Mikulova V, Zima T, Kalousova M
Neoplasma. 2015;62(3):353-64. doi: 10.4149/neo_2015_061.
Receptor for advanced glycation end products (RAGE) plays a central role in the regulation of tissue homeostasis, regeneration and resolution of inflammation, but under pathological conditions RAGE-mediated pathways may induce diminished apoptosis, but enhanced autophagy and cell necrosis. These mechanisms may contribute to malignant transformation, cancer progression and metastases. Soluble RAGE may bind natural RAGE ligands and counteract some of the RAGE-mediated effects. Activation of RAGE was demonstrated in different types of cancer (including colon, pancreatic and breast cancer). Expression of RAGE and serum levels of soluble RAGE may serve as cancer biomarkers and strategies aimed at interfering with RAGE signaling might be promising anticancer drugs.
晚期糖基化终末产物受体（RAGE）在组织稳态、再生及炎症消退的调节中起核心作用，但在病理条件下，RAGE介导的信号通路可能会导致细胞凋亡减少，自噬增强及细胞坏死。这些机制可能促使恶性转化、癌症进展及转移。可溶性RAGE可结合天然RAGE配体并抵消一些RAGE介导的效应。在不同类型的癌症（包括结肠癌、胰腺癌和乳腺癌）中均证实了RAGE的激活。RAGE的表达及可溶性RAGE的血清水平可作为癌症生物标志物，旨在干扰RAGE信号传导的策略可能是有前景的抗癌药物。
