Patregnani Jason T, Brooks Bonnie A, Chorvinsky Elizabeth, Pillai Dinesh K
Division of Cardiac Critical Care Medicine, Children's National Hospital, Washington, DC 20010, USA.
Department of Genomics and Precision Medicine, The George Washington University, Washington, DC 20052, USA.
Children (Basel). 2020 Aug 24;7(9):110. doi: 10.3390/children7090110.
Asthma remains the most common chronic lung disease in childhood in the United States. The receptor for advanced glycation end products (RAGE) has been recognized as both a marker of and participant in pulmonary pathophysiology. While membrane-bound RAGE (mRAGE) perpetuates the type 2 immune response, the soluble form (sRAGE) may act as a decoy receptor for pro-inflammatory ligands. Bronchoalveolar samples from 45 pediatric patients with asthma were obtained. Patients were divided into high and low BAL sRAGE groups using median sRAGE. Descriptive statistical analysis and non-parametric testing were applied. Children in the "high" sRAGE group had a lower median serum eosinophil (0.27 [SE ± 0.04] vs. 0.57 [± 0.06] K/mcl, adjusted = 0.003) and lower serum IgE level (194.4 [± 60.7] vs. 676.2 ± 140.5) IU/mL, adjusted = 0.004) as compared to the "low" sRAGE group. When controlling for age and body mass index percentile, absolute eosinophil count ( = 0.03) and serum IgE ( = 0.043) remained significantly lower in the "high" sRAGE group. Children with asthma and high levels of BAL sRAGE have lower serum eosinophil and IgE levels. These findings are consistent with the hypothesis that sRAGE may act as a decoy receptor by binding ligands that normally interact with mRAGE.
在美国，哮喘仍是儿童中最常见的慢性肺部疾病。晚期糖基化终产物受体（RAGE）已被公认为肺部病理生理学的标志物和参与者。虽然膜结合型RAGE（mRAGE）会使2型免疫反应持续存在，但可溶性形式（sRAGE）可能作为促炎配体的诱饵受体。收集了45例小儿哮喘患者的支气管肺泡样本。使用sRAGE中位数将患者分为高BAL sRAGE组和低BAL sRAGE组。应用描述性统计分析和非参数检验。与“低”sRAGE组相比，“高”sRAGE组儿童的血清嗜酸性粒细胞中位数较低（0.27 [标准误±0.04]对0.57 [±0.06] K/微升，校正P = 0.003），血清IgE水平也较低（194.4 [±60.7]对676.2±140.5）IU/mL，校正P = 0.004）。在控制年龄和体重指数百分位数后，“高”sRAGE组的绝对嗜酸性粒细胞计数（P = 0.03）和血清IgE（P = 0.043）仍显著较低。哮喘患儿且BAL sRAGE水平高者血清嗜酸性粒细胞和IgE水平较低。这些发现与以下假设一致，即sRAGE可能通过结合通常与mRAGE相互作用的配体而作为诱饵受体。
