Fan W, Zhu X, Wu L, Wu Z, Li D, Huang F, He H
Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China.
Eur Rev Med Pharmacol Sci. 2015 Apr;19(8):1520-9.
Propofol is a short-acting intravenous anaesthetic agent and widely used not only in operating rooms but also in the intensive care unit (ICU). Apart from its multiple anaesthetic advantages, the neuroprotective effect of propofol has been demonstrated in diverse models of neuronal injury. The effect of propofol results from activation of gamma-aminobutyric acid (GABA) receptor, modulation excitatory amino acid transmitter system and protecting brain cells against oxidative stress. Moreover, propofol is able to supress apoptosis and inflammation and to regulate neuroprotection-associated proteins or ion homeostasis to act its neuroprotective effects. This review focuses on the research progress of the neuroprotective effects of propofol and its mechanisms of action to date. The implications for possible use for the clinical setting are also discussed.
丙泊酚是一种短效静脉麻醉剂，不仅广泛应用于手术室，还应用于重症监护病房（ICU）。除了具有多种麻醉优势外，丙泊酚的神经保护作用已在多种神经元损伤模型中得到证实。丙泊酚的作用源于γ-氨基丁酸（GABA）受体的激活、对兴奋性氨基酸递质系统的调节以及保护脑细胞免受氧化应激。此外，丙泊酚能够抑制细胞凋亡和炎症，并调节与神经保护相关的蛋白质或离子稳态以发挥其神经保护作用。本文综述了迄今为止丙泊酚神经保护作用及其作用机制的研究进展。还讨论了其在临床应用中的潜在意义。
