Meireles Paula, Lucas Raquel, Martins Ana, Carvalho Ana Cláudia, Fuertes Ricardo, Brito João, Campos Maria José, Mendão Luís, Barros Henrique
EPIUnit-Institute of Public Health, University of Porto, Porto, Portugal Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal.
Grupo Português de Activistas sobre Tratamentos VIH/SIDA (GAT), Lisboa, Portugal.
BMJ Open. 2015 May 12;5(5):e007220. doi: 10.1136/bmjopen-2014-007220.
Newly diagnosed HIV infections among men who have sex with men (MSM) are rising in many European countries. Surveillance tools must be tailored to the current state of the epidemic, and include decentralised prospective monitoring of HIV incidence and behavioural changes in key populations. In this scenario, an open prospective cohort study was assembled--The Lisbon Cohort of MSM--aiming to dynamically monitor the frequency of disease and its predictors.
The Lisbon Cohort of MSM is an ongoing observational prospective study conducted at a community-based voluntary HIV counselling and testing centre in Lisbon, Portugal (CheckpointLX). Men testing negative for HIV, aged 18 or over and reporting having had sex with men are invited to follow-up visits every 6 months. At each evaluation, a face-to-face interview using a structured questionnaire is conducted, and HIV and syphilis rapid tests are performed by trained peer counsellors. From April 2011 to February 2014, 3106 MSM were eligible to the cohort of whom 923 (29.7%) did not participate. The remaining 2183 (70.3%) MSM were enrolled and 804 had at least one follow-up evaluation, for a total of 893 person-years of observation.
The study findings will be disseminated in peer-reviewed journals and presented at national and international conferences. The follow-up of this cohort of HIV-negative MSM will be a valuable tool for monitoring HIV incidence in a setting where limited prospective information existed. Moreover, it will allow for a deeper analytical approach to the study of population time trends and individual changes in risk factors that currently shape the HIV epidemic among MSM.
在许多欧洲国家，男男性行为者（MSM）中新诊断出的艾滋病毒感染病例正在增加。监测工具必须根据当前的疫情状况进行调整，包括对艾滋病毒发病率和关键人群行为变化进行分散式前瞻性监测。在这种情况下，开展了一项开放性前瞻性队列研究——MSM里斯本队列研究，旨在动态监测疾病发生频率及其预测因素。
MSM里斯本队列研究是在葡萄牙里斯本一个社区自愿艾滋病毒咨询和检测中心（CheckpointLX）进行的一项正在进行的观察性前瞻性研究。邀请年龄在18岁及以上、艾滋病毒检测呈阴性且报告有男男性行为的男性每6个月进行一次随访。每次评估时，使用结构化问卷进行面对面访谈，并由经过培训的同伴咨询师进行艾滋病毒和梅毒快速检测。从2011年4月到2014年2月，3106名MSM符合该队列研究的条件，其中923人（29.7%）未参与。其余2183人（70.3%）的MSM被纳入研究，804人至少进行了一次随访评估，总共观察了893人年。
研究结果将在同行评审期刊上发表，并在国内和国际会议上展示。对这一艾滋病毒阴性MSM队列的随访将成为在前瞻性信息有限的情况下监测艾滋病毒发病率的宝贵工具。此外，它将有助于采用更深入的分析方法来研究当前影响MSM中艾滋病毒流行的人群时间趋势和危险因素的个体变化。
