Liu Guowu, Lu Hongyan, Wang Juan, Xia Dongyan, Sun Yanming, Mi Guodong, Wang Liming
Beijing Municipality Center for Disease Control and Prevention, Beijing, China.
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
PLoS One. 2015 Oct 1;10(10):e0138232. doi: 10.1371/journal.pone.0138232. eCollection 2015.
This study investigated HIV and syphilis incidence among men who have sex with men (MSM) in Beijing, China.
An open cohort was established from September 2009 to April 2012. Participants were followed up with every three to four months after recruitment and for thirty-one months in total. Chi-square tests were used to compare demographic and behavioral characteristics between participants who were followed up with and those lost to follow up. Univariate and multivariate Cox proportional hazards regression analyses were used to examine demographic and behavioral associations with HIV and syphilis incidence.
69.7% (699/1,003) of the participants finished at least two follow-up surveys during the study period. Variables which corresponded to increased loss to follow-up included younger age, less education, non-identification of homosexual identity, and migrant status. A total of 1,045 person-years (PYs) and 1,016.4 PYs were followed up for HIV and syphilis incidence estimation, respectively. The HIV incidence was 5.9 per 100 PYs and 7.8 per 100 PYs for syphilis. The predictors for the high HIV incidence included unsafe anal sex, sex after drinking alcohol and STI infection.
HIV incidence increased rapidly within the cohort, but syphilis incidence remained stable and decreased. More research is needed to provide multi-pronged HIV prevention interventions among MSM in order to reduce the increasing burden of HIV and sexually transmitted infections (STIs) in China.
本研究调查了中国北京男男性行为者（MSM）中的艾滋病毒和梅毒发病率。
于2009年9月至2012年4月建立了一个开放队列。参与者在招募后每三到四个月接受一次随访，总共随访31个月。采用卡方检验比较接受随访的参与者与失访参与者的人口统计学和行为特征。使用单因素和多因素Cox比例风险回归分析来检验人口统计学和行为与艾滋病毒和梅毒发病率之间的关联。
69.7%（699/1003）的参与者在研究期间完成了至少两次随访调查。与失访增加相关的变量包括年龄较小、教育程度较低、未认同同性恋身份以及流动状态。分别对1045人年和1016.4人年进行了随访以估计艾滋病毒和梅毒发病率。艾滋病毒发病率为每100人年5.9例，梅毒发病率为每100人年7.8例。艾滋病毒高发病率的预测因素包括不安全的肛交、酒后性行为和性传播感染。
该队列中艾滋病毒发病率迅速上升，但梅毒发病率保持稳定且有所下降。需要开展更多研究，以便在中国男男性行为者中提供多方面的艾滋病毒预防干预措施，以减轻日益增加的艾滋病毒和性传播感染负担。
