Goharian Tina S, Gimsing Anders N, Goetze Jens P, Faber Jens, Andersen Lars B, Grøntved Anders, Jeppesen Jørgen L
a Department of Internal Medicine , Glostrup Hospital, University of Copenhagen , Glostrup , Denmark.
b Department of Clinical Biochemistry , Rigshospitalet, University of Copenhagen , Copenhagen , Denmark.
Blood Press. 2015;24(6):347-52. doi: 10.3109/08037051.2015.1045703. Epub 2015 May 13.
Little is known about blood pressure in relation to circulating natriuretic peptide concentrations and gender in generally healthy adolescents. We studied 15-year-old females and males (n = 335) from the Danish site of the European Youth Heart Study (EYHS). Blood pressure was measured using a standardized protocol, sexual maturity was assessed according to Tanner stage, and as a surrogate for atrial natriuretic peptide, we measured mid-regional pro-atrial natriuretic peptide (MR-proANP) in plasma. Compared with boys, girls had lower systolic blood pressure (SBP) (mean ± SD: 109.6 ± 9.9 mmHg vs 116.9 ± 11.4 mmHg, p < 0.0001) and higher plasma MR-proANP concentrations [median (interquartile range): 42.1 pmol/l (31.9-50.2 pmol/l) vs 36.6 pmol/l (30.6-44.9 pmol/l), p = 0.0046]. When female adolescents were further subdivided according to Tanner stage, there were no differences in blood pressure and plasma MR-proANP concentrations between post-pubertal and pubertal girls (p > 0.17). In contrast, after similar subdivision, post-pubertal boys had higher SBP (mean ± SD: 117.7 ± 11.7 mmHg vs 111.4 ± 7.9 mmHg, p = 0.029) and lower plasma MR-proANP concentrations [median (interquartile range): 36.2 pmol/l (30.6-43.1 pmol/l) vs 46.4 pmol/l (30.3-51.1 pmol/l), p = 0.043] compared with pubertal boys. Given their higher SBP, boys had lower than expected plasma concentrations of MR-proANP compared with girls, and given their higher SBP, post-pubertal boys had lower than expected plasma concentrations of MR-proANP compared with pubertal boys.
在一般健康的青少年中，关于血压与循环利钠肽浓度及性别的关系，我们所知甚少。我们研究了来自欧洲青少年心脏研究（EYHS）丹麦站点的15岁女性和男性（n = 335）。使用标准化方案测量血压，根据坦纳分期评估性成熟度，并且作为心房利钠肽的替代指标，我们测量了血浆中的中段心房利钠肽前体（MR-proANP）。与男孩相比，女孩的收缩压（SBP）较低（均值±标准差：109.6±9.9 mmHg对116.9±11.4 mmHg，p < 0.0001），血浆MR-proANP浓度较高[中位数（四分位间距）：42.1 pmol/l（31.9 - 50.2 pmol/l）对36.6 pmol/l（30.6 - 44.9 pmol/l），p = 0.0046]。当根据坦纳分期对女性青少年进一步细分时，青春期后女孩与青春期女孩之间的血压和血浆MR-proANP浓度没有差异（p > 0.17）。相比之下，在进行类似细分后，青春期后男孩的收缩压较高（均值±标准差：117.7±11.7 mmHg对111.4±7.9 mmHg，p = 0.029），血浆MR-proANP浓度较低[中位数（四分位间距）：36.2 pmol/l（30.6 - 43.1 pmol/l）对46.4 pmol/l（30.3 - 51.1 pmol/l），p = 0.043]，与青春期男孩相比。鉴于男孩的收缩压较高，与女孩相比，他们血浆中MR-proANP的浓度低于预期，并且鉴于青春期后男孩的收缩压较高，与青春期男孩相比，他们血浆中MR-proANP的浓度低于预期。
