Perng Wei, Rifas-Shiman Sheryl L, Hivert Marie-France, Chavarro Jorge E, Sordillo Joanne, Oken Emily
Department of Epidemiology, Colorado School of Public Health, Anschutz Medical Center, Aurora, CO, USA.
Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Ann Hum Biol. 2019 May;46(3):205-214. doi: 10.1080/03014460.2019.1638967. Epub 2019 Jul 15.
Biomarkers of cardiovascular and metabolic risk track from adolescence into adulthood, therefore characterising the direction and magnitude of these changes is an important first step to identifying health trajectories that presage future disease risk. To characterise changes in metabolic biomarkers across early adolescence in a multi-ethnic cohort. Among 891 participants in Project Viva we estimated changes in insulin resistance (HOMA-IR), adipokines, lipids, and SBP between ages 6-10 years and 11-16 years. Next, we used multivariable linear regression to examine associations of sex, baseline overweight/obesity, baseline pubertal status and race/ethnicity with change in the biomarkers during follow-up. Boys exhibited a larger decrement in adiponectin (-0.66 [95% CI = -1.14, -0.18)] ng/mL) and a greater increase in SBP (3.20 [2.10, 4.30] mmHg) than girls. Overweight/obese participants experienced larger increases in HOMA-IR, leptin, and triglycerides; and a steeper decrement in HDL. Pubertal youth showed larger decrements in total and LDL cholesterol than their pre-pubertal counterparts. In comparison to White participants, Black youth experienced a larger magnitude of increase in HOMA-IR, and Hispanic youth exhibited larger decrements in adiponectin and HDL. Change in metabolic biomarkers across early adolescence differed by sex, weight status, pubertal status and race/ethnicity. Some of the metabolic changes may reflect normal physiological changes of puberty, while others may presage future disease risk. Future studies are warranted to link metabolic changes during adolescence to long-term health.
心血管和代谢风险的生物标志物从青春期持续到成年期，因此，明确这些变化的方向和程度是识别预示未来疾病风险的健康轨迹的重要第一步。为了描述多民族队列中青春期早期代谢生物标志物的变化。在生命项目的891名参与者中，我们估计了6至10岁和11至16岁之间胰岛素抵抗（HOMA-IR）、脂肪因子、脂质和收缩压的变化。接下来，我们使用多变量线性回归来研究性别、基线超重/肥胖、基线青春期状态和种族/民族与随访期间生物标志物变化之间的关联。与女孩相比，男孩的脂联素下降幅度更大（-0.66 [95% CI = -1.14, -0.18] ng/mL），收缩压升高幅度更大（3.20 [2.10, 4.30] mmHg）。超重/肥胖参与者的HOMA-IR、瘦素和甘油三酯增加幅度更大；高密度脂蛋白下降幅度更大。青春期青少年的总胆固醇和低密度脂蛋白胆固醇下降幅度比青春期前的同龄人更大。与白人参与者相比，黑人青少年的HOMA-IR增加幅度更大，西班牙裔青少年的脂联素和高密度脂蛋白下降幅度更大。青春期早期代谢生物标志物的变化因性别、体重状况、青春期状态和种族/民族而异。一些代谢变化可能反映了青春期正常的生理变化，而另一些可能预示着未来的疾病风险。有必要进行进一步研究，将青春期的代谢变化与长期健康联系起来。
