红细胞磷脂脂肪酸组成与2型糖尿病炎症相关基因变异之间的相互作用

Interaction between Erythrocyte Phospholipid Fatty Acids Composition and Variants of Inflammation-Related Genes on Type 2 Diabetes.

作者信息

Li Kelei, Huang Tao, Zheng Ju-Sheng, Sun Jianqin, Chen Yanqiu, Xie Hua, Xu Danfeng, Wan Jianbo, Li Duo

机构信息

Department of Food Science and Nutrition, Zhejiang University, Hangzhou, PR China.

出版信息

J Nutrigenet Nutrigenomics. 2014;7(4-6):252-63. doi: 10.1159/000381347. Epub 2015 May 7.

DOI:10.1159/000381347

PMID:25969153

Abstract

AIMS

The present study aimed to investigate the interaction between erythrocyte phospholipid (PL) fatty acids and variants of inflammation-related genes in a Chinese population.

METHODS

A total of 622 patients with type 2 diabetes mellitus (T2DM) and 293 healthy subjects were included. Determination of erythrocyte PL fatty acids composition and genotyping of single nucleotide polymorphisms were conducted by standard methods.

RESULTS

A significant interaction of rs7305618 on HNFIA with C18:2n-6 and C20:4n-6 was observed: T allele carriers (TT+CT) had a higher risk of T2DM than noncarriers only when they had a higher level of C18:2n-6 or C20:4n-6, and the odds ratios (ORs) were 2.59 (95% CI 1.58-4.24; p for interaction=0.005) and 2.49 (95% CI 1.47-4.24; p for interaction=0.021), respectively. A significant interaction of rs8078723 at the intergenic region between PSMD3 and CSF3 with C20:5n-3 was observed: C allele carriers (CC+CT) had a lower risk of T2DM than noncarriers only when they had a higher level of C20:5n-3, and the OR was 0.44 (95% CI 0.26-0.73; p for interaction=0.014).

CONCLUSIONS

rs7305618 and rs8078723 were associated with the risk of T2DM in a Chinese population and were modulated by erythrocyte PL fatty acids composition.

摘要

目的

本研究旨在调查中国人群中红细胞磷脂（PL）脂肪酸与炎症相关基因变体之间的相互作用。

方法

共纳入622例2型糖尿病（T2DM）患者和293例健康受试者。采用标准方法测定红细胞PL脂肪酸组成并进行单核苷酸多态性基因分型。

结果

观察到HNFIA基因上的rs7305618与C18:2n-6和C20:4n-6存在显著相互作用：仅当T等位基因携带者（TT + CT）的C18:2n-6或C20:4n-6水平较高时，他们患T2DM的风险高于非携带者，优势比（OR）分别为2.59（95%CI 1.58 - 4.24；相互作用p值 = 0.005）和2.49（95%CI 1.47 - 4.24；相互作用p值 = 0.021）。观察到PSMD3和CSF3基因间区域的rs8078723与C20:5n-3存在显著相互作用：仅当C等位基因携带者（CC + CT）的C20:5n-3水平较高时，他们患T2DM的风险低于非携带者，OR为0.44（95%CI 0.26 - 0.73；相互作用p值 = 0.014）。