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基于一项荟萃分析,对于 Gustilo ⅢB 型胫骨骨折,非扩髓髓内钉固定是比外固定架更好的选择。

Unreamed Intramedullary Nailing is a better alternative than External Fixator for Gustilo grade IIIB Tibial Fractures based on a meta-analysis.

作者信息

Zhang F, Zhu Y, Li W, Chen W, Tian Y, Zhang Y

机构信息

Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, P.R. China Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, P.R. China.

Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, P.R. China.

出版信息

Scand J Surg. 2016 Jun;105(2):117-24. doi: 10.1177/1457496915586649. Epub 2015 May 12.

Abstract

BACKGROUND AND AIMS

There remains a controversy between unreamed intramedullary nailing and external fixation to treat Gustilo grade IIIB tibial fractures. To evaluate the comparative effectiveness and safeness of both methods for this type of fracture, we performed this meta-analysis.

MATERIALS AND METHODS

Relevant original studies were searched in MEDLINE, EMBASE, China National Knowledge Infrastructure, and Cochrane Central Database (all through February 2014). Studies included in this meta-analysis had to compare the effectiveness or complications and provided sufficient data of interest. The patients treated by both methods were similar statistically in demography and injury mechanism. The Stata 11.0 was used to analyze all data.

RESULTS

Six studies involving 163 participants were included. Unreamed intramedullary nailing was associated with reduced time to union (standardized mean difference, -1.14; 95% confidence interval, -2.04 to -0.24) and lower rates of superficial infection (odds ratio: 0.39; 95% confidence interval: 0.17-0.87) and malunion (odds ratio: 0.27; 95% confidence interval: 0.09-0.78). However, there were no significant differences in other adverse events including delayed union, non-union, deep infection, and fixation failure.

CONCLUSION

The existing evidence supports unreamed intramedullary nailing to be a better method for treating Gustilo grade IIIB tibial fractures, and this might aid in the management of this sever injury.

摘要

背景与目的

在治疗Gustilo IIIB型胫骨骨折时,非扩髓髓内钉固定与外固定之间仍存在争议。为评估这两种方法治疗此类骨折的相对有效性和安全性,我们进行了这项荟萃分析。

材料与方法

在MEDLINE、EMBASE、中国知网和考克兰中央数据库中检索相关原始研究(检索截至2014年2月)。纳入本荟萃分析的研究必须比较有效性或并发症,并提供足够的相关数据。两种方法治疗的患者在人口统计学和损伤机制方面在统计学上相似。使用Stata 11.0分析所有数据。

结果

纳入6项研究,共163名参与者。非扩髓髓内钉固定与骨折愈合时间缩短(标准化均数差,-1.14;95%置信区间,-2.04至-0.24)、浅表感染率降低(比值比:0.39;95%置信区间:0.17 - 0.87)和畸形愈合率降低(比值比:0.27;95%置信区间:0.09 - 0.78)相关。然而,在其他不良事件包括延迟愈合、不愈合、深部感染和固定失败方面,没有显著差异。

结论

现有证据支持非扩髓髓内钉固定是治疗Gustilo IIIB型胫骨骨折的更好方法,这可能有助于管理这种严重损伤。

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