青年成人中灭活甲肝疫苗与减毒活甲肝疫苗免疫原性的比较：一项3年随访研究。
Comparison of Immunogenicity Between Inactivated and Live Attenuated Hepatitis A Vaccines Among Young Adults: A 3-Year Follow-up Study.
作者信息
Liu Xue-en, Chen Hai-ying, Liao Zheng, Zhou Yisheng, Wen Hairong, Peng Shihui, Liu Yan, Li Rui, Li Jie, Zhuang Hui
机构信息
Department of Microbiology and Center of Infectious Disease, School of Basic Medical Sciences, Peking University Health Science Center, Beijing.
Nanchang Center for Disease Control and Prevention, Jiangxi.
出版信息
J Infect Dis. 2015 Oct 15;212(8):1232-6. doi: 10.1093/infdis/jiv213. Epub 2015 May 12.
UNLABELLED
A randomized clinical trial of hepatitis A vaccines (1 or 2 doses of inactivated vaccine [Healive] or 1 dose of live attenuated vaccine [Biovac]) was conducted among adults to evaluate seroprotection rates and geometric mean concentrations of antibody against hepatitis A virus for 36 months. High rates of seroprotection persisted for at least 36 months among adults who received 1 or 2 doses of inactivated hepatitis A vaccine but not among adults who received 1 dose of live attenuated hepatitis A vaccine. The long-term serial monitoring of immunogenicity induced by 1 dose of inactivated hepatitis A vaccine is needed to determine an effective alternative to a 2-dose schedule.
CLINICAL TRIALS REGISTRATION
NCT01865968.
未标注
在成年人中开展了一项甲型肝炎疫苗的随机临床试验（1剂或2剂灭活疫苗[Healive]或1剂减毒活疫苗[Biovac]），以评估36个月内抗甲型肝炎病毒抗体的血清保护率和几何平均浓度。接受1剂或2剂甲型肝炎灭活疫苗的成年人中，高血清保护率持续至少36个月，但接受1剂甲型肝炎减毒活疫苗的成年人中则不然。需要对1剂甲型肝炎灭活疫苗诱导的免疫原性进行长期连续监测，以确定2剂接种方案的有效替代方案。
临床试验注册编号
NCT01865968。
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