用于诱导BALB/c小鼠浆细胞瘤的四种市售降植烷（2,6,10,14-四甲基十五烷）制剂的气相色谱-质谱研究。
Gas chromatographic-mass spectrometric investigation of four commercial pristane (2.6.10.14-tetramethylpentadecane) preparations used for plasmacytoma induction in BALB/c mice.
作者信息
Janz S, Birkenfeld T, Herzschuh R, Storch H
机构信息
Institute of Clinical Immunology, Faculty of Medicine, Karl Marx University Leipzig.
出版信息
Arch Geschwulstforsch. 1989;59(6):415-22.
The most widely studied model of plasmacytomagenesis is the induction of plasmacytomas by intraperitoneal injections of pure alkanes such as pristane (2.6.10.14-tetramethylpentadecane). The presence of small amounts of genotoxic contaminants, that could contribute to the complex oncogenic process, in commercial pristane preparations has not been completely ruled out. Therefore, we conducted a chemical analysis of different pristane preparations applying a combined GC/MS technique, but were not capable of identifying any obvious or putative genotoxic/cancerogenic contaminants.
浆细胞瘤发生最广泛研究的模型是通过腹腔注射纯烷烃如 pristane（2,6,10,14 - 四甲基十五烷）诱导浆细胞瘤。商业pristane制剂中存在少量可能促成复杂致癌过程的基因毒性污染物，这一点尚未完全排除。因此，我们应用GC/MS联用技术对不同的pristane制剂进行了化学分析，但未能鉴定出任何明显的或假定的基因毒性/致癌污染物。
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