Li Mei-Fang, Feng Qi-Ming, Li Lian-Xi, Tu Yin-Fang, Zhang Rong, Dong Xue-Hong, Lu Jun-Xi, Bao Yu-Qian, Jia Wei-Ping, Hu Ren-Ming
Department of Emergency, Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai, China ; Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Key Clinical Center for Metabolic Diseases, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Diseases, Shanghai Key Laboratory of Diabetes Mellitus Shanghai, China.
Department of Emergency, Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai, China.
J Diabetes Investig. 2015 May;6(3):354-9. doi: 10.1111/jdi.12307. Epub 2014 Dec 13.
AIMS/INTRODUCTION: Microalbuminuria is positively related to metabolic syndrome (MetS). Our aim was to investigate whether urinary albumin-to-creatinine ratio (UACR) within the normal range is independently associated with MetS in Chinese community-based patients with type 2 diabetes.
A total of 514 participants (206 males and 308 females; mean age 66 years) with UACR less than 3.5 mg/mmol were enrolled from two downtown areas of Shanghai. The participants were stratified into quartiles according to UACR levels. The prevalence of MetS was assessed and compared among the four groups by binary logistic regression.
Compared with participants with UACRs in the first quartile, the other quartiles had a higher prevalence of MetS (65.9%, 74.4% and 81.3%, respectively, P = 0.001) after adjustment for sex and age. After adjusting for potential confounders, participants in the second to the fourth quartile group had a 1.36-, 1.84- and 2.73-fold risk of MetS, respectively, relative to those in the lowest quartile. Furthermore, UACR, whether as quartile groups or as a continuous variable, is an independent predictor of MetS after fully adjusting for other variables.
These results suggest that UACR even within the normal range is independently associated with MetS in Chinese community-based patients with type 2 diabetes mellitus.
目的/引言：微量白蛋白尿与代谢综合征（MetS）呈正相关。我们的目的是研究在中国社区2型糖尿病患者中，正常范围内的尿白蛋白与肌酐比值（UACR）是否与MetS独立相关。
从上海两个市区招募了514名UACR低于3.5mg/mmol的参与者（206名男性和308名女性；平均年龄66岁）。根据UACR水平将参与者分为四分位数组。通过二元逻辑回归评估并比较四组中MetS的患病率。
与第一四分位数组的参与者相比，在调整性别和年龄后，其他四分位数组的MetS患病率更高（分别为65.9%、74.4%和81.3%，P = 0.001）。在调整潜在混杂因素后，第二至第四四分位数组的参与者患MetS的风险分别是最低四分位数组的1.36倍、1.84倍和2.73倍。此外，无论是作为四分位数组还是作为连续变量，UACR在充分调整其他变量后都是MetS的独立预测因子。
这些结果表明，在中国社区2型糖尿病患者中，即使在正常范围内的UACR也与MetS独立相关。
