作为微型蛋白质结构的受限肽。

Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado at Boulder, 596 University of Colorado at Boulder, Boulder, CO 80309-0596, USA.

ISRN Biochem. 2012 Sep 26;2012:692190. doi: 10.5402/2012/692190. eCollection 2012.

This paper discusses the recent developments of protein engineering using both covalent and noncovalent bonds to constrain peptides, forcing them into designed protein secondary structures. These constrained peptides subsequently can be used as peptidomimetics for biological functions such as regulations of protein-protein interactions.

本文讨论了利用共价键和非共价键来约束肽，促使其形成特定蛋白质二级结构的蛋白质工程的最新进展。这些受约束的肽随后可作为拟肽用于生物功能，如调节蛋白质-蛋白质相互作用。