Karampinos Dimitrios C, Ruschke Stefan, Gordijenko Olga, Grande Garcia Eduardo, Kooijman Hendrik, Burgkart Rainer, Rummeny Ernst J, Bauer Jan S, Baum Thomas
Department of Diagnostic and Interventional Radiology, Technische Universität München, Ismaninger Straße 22, 81675 Munich, Germany.
Department of Orthopedic Surgery, Technische Universität München, Ismaninger Straße 22, 81675 Munich, Germany.
J Osteoporos. 2015;2015:152349. doi: 10.1155/2015/152349. Epub 2015 Apr 19.
Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology. In this study, ten vertebrae were harvested from fresh human cadavers. Trabecular BMD and microstructure parameters were extracted from MDCT. Bone marrow fat fractions were determined using single-voxel MRS. Failure load (FL) values were assessed by destructive biomechanical testing. Significant correlations (P < 0.05) were observed between MRS-based fat fraction and MDCT-based parameters (up to r = -0.72) and MRS-based fat fraction and FL (r = -0.77). These findings underline the importance of the bone marrow in the pathophysiology and imaging diagnostics of osteoporosis.
由于骨髓脂肪过多与骨质流失的病理生理学相关，最近它受到了关注。在本研究中，从新鲜人类尸体上获取了十块椎骨。通过多层螺旋CT（MDCT）提取小梁骨密度和微观结构参数。使用单体素磁共振波谱（MRS）测定骨髓脂肪分数。通过破坏性生物力学测试评估破坏载荷（FL）值。观察到基于MRS的脂肪分数与基于MDCT的参数之间存在显著相关性（P < 0.05，相关系数高达r = -0.72），以及基于MRS的脂肪分数与FL之间存在显著相关性（r = -0.77）。这些发现强调了骨髓在骨质疏松症病理生理学和影像诊断中的重要性。
