Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Best Pract Res Clin Endocrinol Metab. 2021 Jul;35(4):101547. doi: 10.1016/j.beem.2021.101547. Epub 2021 May 1.
Laboratory mice are a crucial preclinical model system for investigating bone marrow adipocyte (BMAd)-bone and BMAd-hematopoiesis interactions. In this review, we evaluate the suitability of mice to model common human diseases related to osteopenia or hematopoietic disorders, point out consistencies and discrepancies among different studies, and provide insights into model selection. Species, age, sex, skeletal site, and treatment protocol should all be considered when designing future studies.
实验室小鼠是研究骨髓脂肪细胞（BMAd）-骨和 BMAd-造血相互作用的重要临床前模型系统。在这篇综述中，我们评估了小鼠模拟与骨质疏松或造血障碍相关的常见人类疾病的适宜性，指出了不同研究之间的一致性和差异，并深入了解了模型选择。在设计未来的研究时，应考虑物种、年龄、性别、骨骼部位和治疗方案等因素。
